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BIA 10-2474

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Purity:99.79%

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COA LCMS HPLC HNMR

BIA 10-2474

Catalog No. T3354Cas No. 1233855-46-3

BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest of the body other than the brain and spinal cord). BIA 10-2474(BIA10-2474) interacts with the human endocannabinoid system. BIA 10-2474(BIA10-2474) was in development for the treatment of a range of different medical conditions from anxiety to Parkinson's disease, also for the treatment of chronic pain of multiple sclerosis, Y, hypertension or the treatment of obesity.

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$47	In Stock
10 mg	$84	In Stock
25 mg	$158	In Stock
50 mg	$259	In Stock
100 mg	$413	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Product Introduction

Bioactivity

Description	BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest of the body other than the brain and spinal cord). BIA 10-2474(BIA10-2474) interacts with the human endocannabinoid system. BIA 10-2474(BIA10-2474) was in development for the treatment of a range of different medical conditions from anxiety to Parkinson's disease, also for the treatment of chronic pain of multiple sclerosis, Y, hypertension or the treatment of obesity.
In vitro	ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC50s of 50-70 mg/kg (i.p.) in various brain regions. IC50 values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus)[1].
In vivo	In January 2016, a Phase I clinical trial involving the drug BIA 10-2474 experienced severe adverse events (SAE), including a fatality. Investigations into the trial's failure will explore various potential causes, such as off-target effects, miscalculated dosage, unforeseen immune responses, interspecies variability, and cumulative dose toxicity[2].
Alias	BIA10-2474

Chemical Properties

Molecular Weight	300.36
Formula	C16H20N4O2
Cas No.	1233855-46-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4 mg/mL(13.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3293 mL	16.6467 mL	33.2934 mL	166.4669 mL
5 mM	0.6659 mL	3.3293 mL	6.6587 mL	33.2934 mL
10 mM	0.3329 mL	1.6647 mL	3.3293 mL	16.6467 mL

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