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TETRAHYDROPIPERINE
🥰Excellent
Catalog No. T5786Cas No. 23434-88-0
Alias Cosmoperine
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
TETRAHYDROPIPERINE
🥰Excellent
Purity: 99.51%
Catalog No. T5786Alias CosmoperineCas No. 23434-88-0
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $35 | In Stock | |
| 50 mg | $52 | In Stock | |
| 100 mg | $73 | In Stock | |
| 200 mg | $106 | In Stock |
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CitedSelect Batch
Purity:99.51%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. |
| Targets&IC50 | CYP450:23 µM , MOCD:25 µM, TRPV1:6.3 µM |
| In vivo | TETRAHYDROPIPERINE is an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3 μM)[1]. It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50 = 23 μM) and 7-methoxycoumarin O-demethylase (MOCD) activity (IC50 = 25 μM) in rat liver microsomes[2].Tetrahydropiperine increases skin pigmentation in a mouse model of vitiligo when 100 μl of a 175 mM solution is administered topically, an effect that can be enhanced by subsequent suberythemal ultraviolet radiation (UVR)[3]. |
| Animal Research | The test compounds were PIP [5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylpiperidine], tetrahydropiperine [THP, 5-(3,4-methylenedioxyphenyl)-pentanoylpiperidine], a cyclohexyl analogue of piperine [CHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylcyclohexylamine], and reduced CHP [rCHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentanoylcyclohexylamine].?Sparsely pigmented, HRA/Skh-II mice were randomized to receive topical treatment with test compounds or vehicle twice a day for five days a week, with or without ultraviolet (UV) irradiation on 3 days a week.?Treatment was either continuous or interrupted to evaluate fading and repigmentation.?Skin inflammation and pigmentation were evaluated regularly during treatment.?DOPA+ melanocytes were determined histologically at the termination of treatment[3]. |
| Alias | Cosmoperine |
| Molecular Weight | 289.37 |
| Formula | C17H23NO3 |
| Cas No. | 23434-88-0 |
| Smiles | O=C(CCCCc1ccc2OCOc2c1)N1CCCCC1 |
| Relative Density. | 1.156g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 57 mg/mL (196.97 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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