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AG 045572

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Catalog No. T22025Cas No. 263847-55-8

AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.

AG 045572

AG 045572

🥰Excellent
Purity: 98.99%
Catalog No. T22025Cas No. 263847-55-8
AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.
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1 mg116 €In Stock
5 mg234 €In Stock
10 mg329 €In Stock
25 mg533 €In Stock
50 mg747 €In Stock
100 mg1.016 €In Stock
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Purity:98.99%
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Product Introduction

Bioactivity
Description
AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.
Targets&IC50
GnRH receptor (human):6.0 nM(ki), GnRH receptor (rat):3.8 nM(ki)
In vitro
AG 045572 (10 μM, 40 min, for human liver microsomes; 10 μM, 10 min, for male rat liver microsomes; 1 μM, 10 min, for female rat liver microsomes) is metabolized by CYP3A in both rats and humans. The Km values in male and female human and female rat liver microsomes and expressed CYP3A4 and CYP3A5 were similar (0.39, 0.27, 0.28, 0.25, and 0.26 μM, respectively), while the Km values in male rat liver microsomes were 1.5 μM, indicating that AG-045572 is metabolized by different CYP3A isoenzymes in male and female rats.[1]
In vivo
AG 045572 (10 mg/kg (i.v.) or 20 mg/kg (p.o.), one time) in intact male rats showed moderate T1/2, CL and Vss but low oral bioavailability, with The bioavailability is higher in female rats (24%), and the pharmacokinetics in castrated male rats are similar to those in female rats.[1]
The pharmacokinetics of AG 045572 (40 mg/kg; i.m.; twice a day for 3 days) in intact male rats changed, and the parameters were similar to those in female and castrated male rats.[1]
Chemical Properties
Molecular Weight491.62
FormulaC30H37NO5
Cas No.263847-55-8
SmilesCC1(C)C=2C(=CC(C)=C(CC=3OC(C(NC4=C(OC)C=C(OC)C=C4OC)=O)=CC3)C2)C(C)(C)CC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (111.88 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0341 mL10.1705 mL20.3409 mL101.7046 mL
5 mM0.4068 mL2.0341 mL4.0682 mL20.3409 mL
10 mM0.2034 mL1.0170 mL2.0341 mL10.1705 mL
20 mM0.1017 mL0.5085 mL1.0170 mL5.0852 mL
50 mM0.0407 mL0.2034 mL0.4068 mL2.0341 mL
100 mM0.0203 mL0.1017 mL0.2034 mL1.0170 mL

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