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Galangin

🥰Excellent
Catalog No. T3668Cas No. 548-83-4
Alias Norizalpinin, 3,5,7-Trihydroxyflavone

Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.

Galangin

Galangin

🥰Excellent
Purity: 99.93%
Catalog No. T3668Alias Norizalpinin, 3,5,7-TrihydroxyflavoneCas No. 548-83-4
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$47In Stock
25 mg$77In Stock
50 mg$123In Stock
100 mg$217In Stock
500 mg$543In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Purity:99.93%
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Product Introduction

Bioactivity
Description
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
In vitro
Through thin-layer chromatography, it has been demonstrated that Galangin impedes the catabolic decomposition of DMBA in a dose-dependent fashion and obstructs the generation of DMBA-DNA adducts, thereby averting DMBA-related suppression of cell proliferation. Additionally, Galangin robustly curtails CYP1A1 enzyme activity in a dose-responsive manner within both intact cells and DMBA-exposed cell-derived microsomes, as ascertained through ethoxyresorufin-O-deethylase activity assays. The inhibition of CYP1A1 by Galangin occurs through a noncompetitive mechanism, as evidenced by double-reciprocal plot analysis. Moreover, Galangin elevates CYP1A1 mRNA levels, suggesting potential aryl hydrocarbon receptor agonism, yet it counteracts the DMBA or TCDD-triggered upregulation of CYP1A1 mRNA and promoter-driven transcription[1]. Furthermore, Galangin administration hampers cell proliferation while propelling autophagy at 130 μM and apoptosis at 370 μM. Specifically, in HepG2 cells, Galangin induces autophagosome accumulation, enhances microtubule-associated protein light chain 3 levels, and augments the proportion of vacuolated cells, alongside a surge in p53 expression. The Galangin-induced autophagic response is mitigated by p53 inhibition in HepG2 cells, while p53 overexpression in Hep3B cells normalizes the elevated vacuole presence[2].
Cell Research
Cells (5.0×103) are seeded and treated with different concentrations of galangin for different periods of time in 96-well plates. The number of viable cells in each well is determined by adding 10 μL of 5 mg/mL MTT solution. Following the 4 hour incubation at 37°C, the cells are dissolved in a 100 μL solution containing 20% SDS and 50% dimethy formamide. The optical densities are quantified at a test wavelength of 570 nm with a reference wavelength of 630 nm using a Varioskan Flash Reader spectrophotometer.
AliasNorizalpinin, 3,5,7-Trihydroxyflavone
Chemical Properties
Molecular Weight270.24
FormulaC15H10O5
Cas No.548-83-4
SmilesOc1cc(O)c2c(c1)oc(-c1ccccc1)c(O)c2=O
Relative Density.1.579 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble
DMSO: 60 mg/mL (222.06 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7004 mL18.5021 mL37.0041 mL185.0207 mL
5 mM0.7401 mL3.7004 mL7.4008 mL37.0041 mL
10 mM0.3700 mL1.8502 mL3.7004 mL18.5021 mL
20 mM0.1850 mL0.9251 mL1.8502 mL9.2510 mL
50 mM0.0740 mL0.3700 mL0.7401 mL3.7004 mL
100 mM0.0370 mL0.1850 mL0.3700 mL1.8502 mL

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