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Pradefovir mesylate

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Pradefovir mesylate

Catalog No. T19526Cas No. 625095-61-6

Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.

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Pack Size	Price	Availability
1 mg	$213	In Stock
5 mg	$455	In Stock
10 mg	$672	In Stock
25 mg	$1,060	In Stock
50 mg	$1,430	In Stock
100 mg	$1,920	In Stock

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Product Introduction

Bioactivity

Description	Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.
In vitro	Pradefovir was converted to PMEA in human liver microsomes with a K(m) of 60 microM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 ml/min.?Addition of ketoconazole and monoclonal antibody 3A4 significantly inhibits the conversion of pradefovir to PMEA in human liver microsomes, suggesting the predominant role of CYP3A4 in the metabolic activation of pradefovir.?Pradefovir at 0.2, 2, and 20 microM was neither a direct inhibitor nor a mechanism-based inhibitor of CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, and CYP1A2 in human liver microsomes.
In vivo	In rats, the liver was the site of metabolic activation of pradefovir, whereas the small intestine did not play a significant role in the metabolic conversion of pradefovir to PMEA.?Daily oral dosing (300 mg/kg) to rats for 8 days showed that pradefovir was not an inducer of P450 enzymes in rats[1].?
Alias	Pradefovir mesilate, Remofovir mesylate, Hepavir B

Chemical Properties

Molecular Weight	519.9
Formula	C18H23ClN5O7PS
Cas No.	625095-61-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 120 mg/mL (230.81 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9234 mL	9.6172 mL	19.2345 mL	96.1723 mL
5 mM	0.3847 mL	1.9234 mL	3.8469 mL	19.2345 mL
10 mM	0.1923 mL	0.9617 mL	1.9234 mL	9.6172 mL
20 mM	0.0962 mL	0.4809 mL	0.9617 mL	4.8086 mL
50 mM	0.0385 mL	0.1923 mL	0.3847 mL	1.9234 mL
100 mM	0.0192 mL	0.0962 mL	0.1923 mL	0.9617 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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