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Talarozole
🥰Excellent
Catalog No. T7370Cas No. 201410-53-9
Alias R115866
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) that inhibits CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively, for treating acne, psoriasis, and other keratinization disorders.
Talarozole
🥰Excellent
Catalog No. T7370Alias R115866Cas No. 201410-53-9
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) that inhibits CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively, for treating acne, psoriasis, and other keratinization disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 62 € | In Stock | |
| 5 mg | 130 € | In Stock | |
| 10 mg | 168 € | In Stock | |
| 25 mg | 236 € | In Stock | |
| 50 mg | 305 € | In Stock | |
| 100 mg | 463 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 107 € | In Stock |
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Purity:≥95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) that inhibits CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively, for treating acne, psoriasis, and other keratinization disorders. |
| Targets&IC50 | CYP26B1/A1:0.46/5.1 nM (IC50) |
| Alias | R115866 |
| Molecular Weight | 377.51 |
| Formula | C21H23N5S |
| Cas No. | 201410-53-9 |
| Smiles | CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1 |
| Relative Density. | 1.26 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 36 mg/mL (95.36 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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