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Tienilic Acid

Catalog No. T36125 CAS 40180-04-9

Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity

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Tienilic Acid, CAS 40180-04-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 147.00
50 mg	In stock	$ 218.00
100 mg	In stock	$ 323.00
200 mg	In stock	$ 483.00
500 mg	In stock	$ 776.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity

In vivo

In female and male Sprague-Dawley rats, Tienilic Acid decreased blood pressure and serum uric acid at 30 mg/kg. Tienilic acid decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg. Tienilic Acid significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly. Tienilic Acid also induced unicellular necrosis of small groups of liver cells[2].

Molecular Weight	331.17
Formula	C13H8Cl2O4S
CAS No.	40180-04-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Acetone-d6: 250 mg/mL (754.90 mM), Sonication and heating to 80℃ are recommended.

DMSO: ≥ 33.1 mg/mL

References and Literature

1. Levron, J.C., et al. Pharmacokinetic study of 2,3-dichloro 4- (2-thienyl keto14C) phenoxyacetic acid (tienilic acid) in animals. European Journal of Drug Metabolism and Pharmacokinetics 2, 107–120 (1977). 2. Oker-Blom C, et al. Toxicological studies on tienilic acid in rats. Toxicol Lett. 1980;6(2):93-99. 3. Lemieux G, et al, Baverel G. Metabolic effects in man of tienilic acid, a new diuretic with uricosuric properties. Nephron. 1978;20(1):54-64.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Bioactive Compounds Library Max Human Metabolite Library ReFRAME Related Library Metabolism Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Tienilic Acid 40180-04-9 Metabolism P450 ANP 3624 Inhibitor Uricosuric Diuretic inhibit Hepatotoxicity ANP3624 Ticrynafen ANP-3624 inhibitor

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