Shopping Cart
- Remove All
Your shopping cart is currently empty
Hypaconitine
Catalog No. T6S0630Cas No. 6900-87-4
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, possesses anti-inflammatory activity and is widely used to treat rheumatism.
Hypaconitine
Catalog No. T6S0630Cas No. 6900-87-4
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, possesses anti-inflammatory activity and is widely used to treat rheumatism.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $117 | In Stock | |
| 25 mg | $228 | In Stock | |
| 50 mg | $387 | In Stock | |
| 100 mg | $568 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $106 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Hypaconitine"
Naringin
Cited
Naringoside
T059510236-47-2
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
- $35
Size
QTY
CitedGlucosamine Cited
D-Glucosamine, Chitosamine
T04293416-24-8
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
- $50
Size
QTY
CitedNaringenin Cited
S-Dihydrogenistein, Salipurol, Pelargidanon, NSC 34875, NSC 11855, Naringetol
T2838480-41-1
Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
- $50
Size
QTY
CitedApremilast
CC-10004
T2923608141-41-9
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
- $43
Size
QTY
Tebuconazole
T17022107534-96-3
Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively).
- $50
Size
QTY
Lenalidomide Cited
CC-5013
T1642191732-72-6
Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.
- $36
Size
QTY
CitedFenofibrate Cited
Procetofen, Lipantil, Lipanthyl
T114949562-28-9
Fenofibrate (Lipanthyl) is a PPARα agonist (EC50=30 μM) and is selective. Fenofibrate also inhibits cytochrome P450 isoforms, such as CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4. Fenofibrate exhibits antihyperlipidemic activity.
- $32
Size
QTY
CitedApigenin Cited
NSC 83244, LY 080400, C.I. Natural Yellow 1, Apigenol, 4',5,7-Trihydroxyflavone
T2175520-36-5
Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sleep medication. Apigenin has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
- $45
Size
QTY
CitedTauroursodeoxycholate
Cited
Ursodeoxycholyltaurine, UR 906, TUDCA, Tauroursodeoxycholic Acid, Taurolite
T253214605-22-2
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
- $50
Size
QTY
CitedFisetin Cited
T2879528-48-3
Fisetin belongs to a group of natural flavonols with a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects.
- $41
Size
QTY
Cited1-Aminobenzotriazole
ABT, 3-Aminobenzotriazole
T59531614-12-6
1-Aminobenzotriazole (ABT) (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.
- $41
Size
QTY
1-Ethynylnaphthalene
T742715727-65-8
1-Ethynylnaphthalene [1-EN] is a selective inhibitor of cytochrome P450 IB1 (CYP1B1).
- $41
Size
QTY
Select Batch
Purity:99.63%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hypaconitine, an active and highly toxic constituent derived from Aconitum species, possesses anti-inflammatory activity and is widely used to treat rheumatism. |
| In vitro | Hypaconitine (0.08-2 microM) depressed the nerve-evoked twitch tension, without affecting the contraction evoked by stimulation of the muscle,At the concentrations of hypaconitine (up to 5 microM)that depressed the nerve-evoked twitch tension, the resting membrane potential of the muscle cells was unchanged. Hypaconitine (0.1-2 microM) blocked the end-plate potential (epp), without affecting the amplitude of the miniature epp (mepp). The quantal content of end-plate potentials was decreased by these agents in parallel with the decrement in amplitude. |
| Animal Research | Adult Wistar rats were orally administered?Hypaconitine?(0.23, 0.69, 2.07 mg/kg per day), liquiritin (20 mg/kg per day), or?Hypaconitine?(2.07 mg/kg per day) plus liquiritin (20 mg/kg per day) for seven consecutive days. The mRNA expression levels of CaM and Cx43 in rat myocardial tissue were determined by real-time quantitative PCR. The protein contents of CaM and phosphorylated Cx43 (Ser368) were determined by Western blot |
| Molecular Weight | 615.71 |
| Formula | C33H45NO10 |
| Cas No. | 6900-87-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (81.21 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Hypaconitine | purchase Hypaconitine | Hypaconitine cost | order Hypaconitine | Hypaconitine chemical structure | Hypaconitine in vitro | Hypaconitine formula | Hypaconitine molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.