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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $172 | In Stock | |
25 mg | $339 | In Stock | |
50 mg | $547 | In Stock | |
100 mg | $789 | In Stock | |
500 mg | $1,630 | In Stock | |
1 mL x 10 mM (in DMSO) | $116 | In Stock |
Description | CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 can be extracted from liver and kidney and has the potential to treat kidney diseases. |
In vitro | CYP4A11/CYP4F2-IN-2 suppresses 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 29 nM.[1] |
In vivo | CYP4A11/CYP4F2-IN-2 (0.03-1 mg/kg; a single p.o.) effectively inhibits renal 20-HETE production in rats in a dose-dependent manner.[1] CYP4A11/CYP4F2-IN-2 (0.5 mg/kg; i.v.) demonstrates a low clearance rate (1430 mL/h/kg), a moderate volume of distribution (763 mL/kg), and short half-life (0.424 h) in mice.[1] CYP4A11/CYP4F2-IN-2 (1 mg/kg; i.v.) exhibits low clearance (226 mL/h/kg), moderate volume of distribution (839 mL/kg), and a half-life of (3.01 h) in SD rats.[1] CYP4A11/CYP4F2-IN-2 (1 mg/kg; p.o.) shows a maximum concentration (623 ng/mL), a half-life of (3.03 h), and high bioavailability (97.7%) in SD rats.[1] |
Molecular Weight | 300.36 |
Formula | C16H20N4O2 |
Cas No. | 2126874-77-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (74.9 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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