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Danshensu sodium salt
Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.
Catalog No. T2944Cas No. 67920-52-9
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Purity:99.52%
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Danshensu sodium salt
Catalog No. T2944Cas No. 67920-52-9
Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $45 | In Stock | |
| 25 mg | $60 | In Stock | |
| 50 mg | $85 | In Stock | |
| 100 mg | $100 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. |
| In vitro | The compound Sodium Danshensu was administered in two different methods to assess its toxicity. When orally administered to mice, the LD50 was determined to be 2356.33 mg/kg; conversely, when injected intravenously into rats, the LD50 was found to exceed 1500 mg/kg. |
| In vivo | Danshensu is an effective free radical scavenger and antioxidant. Sodium danshensu exerts a biphasic action on vascular tension, where a low dose may induce minor contractions through a momentary increase in Ca2+ influx, while higher doses predominantly cause significant vasodilation by facilitating the opening of non-selective K+ channels and small-conductance Ca2+-sensitive K+ channels in vascular smooth muscle cells. Additionally, sodium danshensu inhibits vasoconstriction induced by norepinephrine and CaCl2 in a free Ca(2+) medium. Pre-treatment with sodium danshensu can suppress vasoconstriction triggered by norepinephrine and KCl in a dose-dependent manner. |
| Alias | Sodium Danshensu, (±)-DanShenSu sodium salt, (±)-DanShenSu sodium sal |
| Molecular Weight | 220.16 |
| Formula | C9H9NaO5 |
| Cas No. | 67920-52-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 2 mg/mL (9.08 mM) DMSO: 50 mg/mL (227.11 mM), Heating is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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