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Sulfaphenazole

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Purity:99.67%

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COA HNMR LCMS

Sulfaphenazole

Catalog No. T4567Cas No. 526-08-9

Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

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Pack Size	Price	Availability	Quantity
100 mg	$50	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description

Alias

Plisulfan, Raziosulfa, Depocid, Depotsulfonamide

Chemical Properties

Molecular Weight	314.36
Formula	C15H14N4O2S
Cas No.	526-08-9

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 0.5 mg/mL

DMSO: 50 mg/mL (159.05 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1811 mL	15.9053 mL	31.8107 mL	159.0533 mL
5 mM	0.6362 mL	3.1811 mL	6.3621 mL	31.8107 mL
10 mM	0.3181 mL	1.5905 mL	3.1811 mL	15.9053 mL
20 mM	0.1591 mL	0.7953 mL	1.5905 mL	7.9527 mL
50 mM	0.0636 mL	0.3181 mL	0.6362 mL	3.1811 mL
100 mM	0.0318 mL	0.1591 mL	0.3181 mL	1.5905 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc