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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $58 | In Stock | |
2 mg | $78 | In Stock | |
5 mg | $118 | In Stock | |
10 mg | $187 | In Stock | |
25 mg | $319 | In Stock | |
50 mg | $460 | In Stock | |
100 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $135 | In Stock |
Description | CYP11B2-IN-1 is an effective and selective inhibitor of CYP11B2 with IC50s of 2.3 nM and 142 nM for CYP11B2 and CYP11B1. |
In vitro | The IC50 of CYP11B2-IN-1 for CYP19 is 1021 nM[1]. |
In vivo | CYP11B2-IN-1 dose-dependently produces aldosterone lowering efficacy without affecting cortisol levels in rhesus pharmacodynamic models. CYP11B2-IN-1 (0.01 and 0.3 mg/kg; i.v.) reduces aldosterone AUC of 62% and 95%, respectively[1]. |
Molecular Weight | 311.35 |
Formula | C18H18FN3O |
Cas No. | 1356479-78-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (160.59 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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