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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $60 | In Stock | |
5 mg | $147 | In Stock | |
10 mg | $239 | In Stock | |
25 mg | $478 | In Stock | |
50 mg | $688 | In Stock | |
100 mg | $996 | In Stock | |
1 mL x 10 mM (in DMSO) | $162 | In Stock |
Description | Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research. |
In vitro | Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50?of 4.5 nM |
In vivo | Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus |
Alias | TAK-935, OV935 |
Molecular Weight | 373.45 |
Formula | C23H23N3O2 |
Cas No. | 1429505-03-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (267.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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