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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $191 | In Stock | |
5 mg | $480 | In Stock | |
10 mg | $687 | In Stock | |
25 mg | $1,080 | In Stock | |
50 mg | $1,480 | In Stock |
Description | Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer. |
In vitro | Vorozole inhibits aromatase activity in FSH-stimulated rat granulosa cells with an IC 50 s of 1.4 nM.[3] |
In vivo | Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 days; Female Sprague-Dawley rats), while displaying an antitumor effect, also elevates serum levels of insulin-like growth factor (IGF)-1 and testosterone.[3] Vorozole (0.8-1.25 mg/kg; p.o.; 5 days; Female Sprague-Dawley rats), in a dose-dependent manner, decreased uterine weight and effectively suppressed tumor aromatase in ovariectomized nude mice.[3] |
Alias | R83839, R 83839, R-83839, (+)-Vorozole, R83842 |
Molecular Weight | 324.77 |
Formula | C16H13ClN6 |
Cas No. | 129731-10-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (153.96 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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