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GYKI-47261 dihydrochloride
🥰Excellent
Catalog No. T38601Cas No. 1217049-32-5
Alias GYKI47261 dihydrochloride
GYKI-47261 dihydrochloride is an orally active and selective AMPA receptor antagonist, also a CYP2E1 inducer with broad anticonvulsant and neuroprotective activity, used in neurological and cardiovascular research.
GYKI-47261 dihydrochloride
🥰Excellent
Purity: 99.36%
Catalog No. T38601Alias GYKI47261 dihydrochlorideCas No. 1217049-32-5
GYKI-47261 dihydrochloride is an orally active and selective AMPA receptor antagonist, also a CYP2E1 inducer with broad anticonvulsant and neuroprotective activity, used in neurological and cardiovascular research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $718 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock |
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CitedSelect Batch
Purity:99.36%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GYKI-47261 dihydrochloride is an orally active and selective AMPA receptor antagonist, also a CYP2E1 inducer with broad anticonvulsant and neuroprotective activity, used in neurological and cardiovascular research. |
| Targets&IC50 | AMPA:2.5 μM |
| In vitro | GYKI-47261 dihydrochloride inhibits AMPA or rhodosine-induced whole cell currents in isolated neurons. [1] |
| In vivo | GYKI-47261 dihydrochloride (200 mg/kg orally) is highly active in transient focal ischemia models. Antiischemic effect of GYKI-47261 dihydrochloride (6 mg/kg iv) in rats with transient focal cerebral ischemia. GYKI-47261 dihydrochloride effectively alleviates tremor induced by oxotremorine, a cholinergic agonist, in the treatment of Parkinson's disease. [1] |
| Alias | GYKI47261 dihydrochloride |
| Molecular Weight | 395.71 |
| Formula | C18H17Cl3N4 |
| Cas No. | 1217049-32-5 |
| Smiles | ClC1=CC(C(C2=CC=C(N)C=C2)=NN3C=C(C)N=C3C4)=C4C=C1.Cl.Cl |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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