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(+)-Ketoconazole
🥰Excellent
Catalog No. T13464Cas No. 142128-59-4
Alias (+)-R41400, (+)-R 41400, (+)-Ketoconazol
(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.
(+)-Ketoconazole
🥰Excellent
Catalog No. T13464Alias (+)-R41400, (+)-R 41400, (+)-KetoconazolCas No. 142128-59-4
(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.
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Product Introduction
Bioactivity
Chemical Properties
| Description | (+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis. |
| In vitro | (+)-Ketoconazole, an imidazole derivative, is a broad-spectrum systemic antifungal agent with oral activity that effectively inhibits CYP3A4 activity in human liver microsomes. [1] |
| In vivo | Perinatal exposure of female rats to (+)-Ketoconazole (3-6-12mg/kg.d), adolescence or adulthood (3-12-48mg/kg.d) showed that perinatal exposure to the highest dose of (+)-Ketoconazole delayed the maturation of GnRH secretion before puberty, while adolescent or adult exposure had no effect on GnRH pulsation. [2] |
| Alias | (+)-R41400, (+)-R 41400, (+)-Ketoconazol |
| Molecular Weight | 531.43 |
| Formula | C26H28Cl2N4O4 |
| Cas No. | 142128-59-4 |
| Smiles | C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)=O)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (37.63 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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