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XL388

🥰Excellent
Catalog No. T6030Cas No. 1251156-08-7

XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.

XL388

XL388

🥰Excellent
Purity: 99.53%
Catalog No. T6030Cas No. 1251156-08-7
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
2 mg$53In Stock
5 mg$89In Stock
10 mg$143In Stock
25 mg$297In Stock
50 mg$489In Stock
100 mg$716In Stock
1 mL x 10 mM (in DMSO)$109In Stock
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Purity:99.53%
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Product Introduction

Bioactivity
Description
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
Targets&IC50
mTOR:9.9 nM
In vitro
In vitro, XL388 inhibited the activity of solid and hematopoietic tumor cell lines as well as the proliferation of MCF-7 cell line (IC50: 1.37 μM). xL388 inhibited mTORC1 phosphorylation of p70S6K (T389) in MCF-7 cells (IC50: 94 nM). xL388 inhibited the phosphorylation of mTORC2 by AKT (S473) (IC50 : 350 nM).
In vivo
In vitro, XL388 inhibited the activity of solid and hematopoietic tumor cell lines as well as the proliferation of MCF-7 cell line (IC50: 1.37 μM). xL388 inhibited mTORC1 phosphorylation of p70S6K (T389) in MCF-7 cells (IC50: 94 nM). xL388 inhibited the phosphorylation of mTORC2 by AKT (S473) (IC50 : 350 nM).
Kinase Assay
Determination of Enzyme IC50 Values: IC50 values are determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled-enzyme format, according to the manufacturer's protocol (Z'-LYTE@biochemical assay). Kinase selectivity is determined using both the Z'-LYTE@ and Adapta@ kinase assay format.
Chemical Properties
Molecular Weight455.5
FormulaC23H22FN3O4S
Cas No.1251156-08-7
SmilesCc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O
Relative Density.1.354 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 22 mg/mL (48.3 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1954 mL10.9769 mL21.9539 mL109.7695 mL
5 mM0.4391 mL2.1954 mL4.3908 mL21.9539 mL
10 mM0.2195 mL1.0977 mL2.1954 mL10.9769 mL
20 mM0.1098 mL0.5488 mL1.0977 mL5.4885 mL

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