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Verapamil hydrochloride
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
Catalog No. T1010Cas No. 152-11-4
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Purity:99.98%
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Verapamil hydrochloride
Catalog No. T1010Alias Verapamil HCl, Manidon, Calcan hydrochloride, (±)-Verapamil hydrochloridCas No. 152-11-4
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $41 | In Stock | |
| 1 g | $48 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock |
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Bioactivity
Chemical Properties
| Description | Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent. |
| In vitro | Verapamil exhibits antiarrhythmic properties, reduces myocardial oxygen consumption in rats, and preserves Cx43 protein. |
| In vivo | Verapamil and Diltiazem essentially inhibit the hydrolase activity of recombinant CES2, with inhibition constants (Ki) of 0.25 ± 0.02 μM and 3.84 ± 0.99 μM, respectively. |
| Cell Research | Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1]. |
| Alias | Verapamil HCl, Manidon, Calcan hydrochloride, (±)-Verapamil hydrochlorid |
| Molecular Weight | 491.06 |
| Formula | C27H39ClN2O4 |
| Cas No. | 152-11-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (101.82 mM)  H2O: 24.6 mg/mL (50 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Ca channelsVerapamil hydrochlorideVerapamilinhibitInhibitorVerapamil HydrochloridepressurePgpABCB1Verapamil hydrochloridP-gpCa2+ channelsP-glycoproteinlysosomotropicCalcium ChannelMDR1high(±)-VerapamilanginaPalbociclibCytochrome P450Calcan HydrochlorideCD243Cluster of differentiation 243CYP3A4Multidrug resistance protein 1antiarrhythmicCYPsblood
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