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Seviteronel
🥰Excellent
Catalog No. T13312LCas No. 1610537-15-9
Alias VT-464
Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist used in breast and prostate cancer research.
Seviteronel
🥰Excellent
Purity: 100%
Catalog No. T13312LAlias VT-464Cas No. 1610537-15-9
Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist used in breast and prostate cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $113 | In Stock | |
| 5 mg | $273 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $675 | In Stock | |
| 50 mg | $959 | In Stock | |
| 100 mg | $1,280 | In Stock |
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Purity:100%
ee:99.46%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist used in breast and prostate cancer research. |
| Targets&IC50 | CYP17 Lyase (human):69 nM |
| In vitro | Seviteronel (VT-464) selectively inhibits CYP17 17,20-lyase to suppress androgen production without causing mineralocorticoid excess or cortisol depletion[2]. |
| In vivo | Seviteronel(100 mg/kg bid; oral administration for 25 days) reduced tumor volume in castrated male mice with xenografts[2]. |
| Alias | VT-464 |
| Molecular Weight | 399.34 |
| Formula | C18H17F4N3O3 |
| Cas No. | 1610537-15-9 |
| Smiles | CC(C)[C@@](O)(c1c[nH]nn1)c1ccc2cc(OC(F)F)c(OC(F)F)cc2c1 |
| Relative Density. | 1.393 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (100.16 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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