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Seviteronel

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Purity:99.83%

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COA LCMS

Seviteronel

Catalog No. T13312LCas No. 1610537-15-9

Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist for the study of breast and prostate cancer.

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Pack Size	Price	Availability	Quantity
1 mg	$113	In Stock

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Product Introduction

Bioactivity

Description	Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist for the study of breast and prostate cancer.
In vitro	Seviteronel (VT-464) selectively inhibits CYP17 17,20-lyase to suppress androgen production without causing mineralocorticoid excess or cortisol depletion[2].
In vivo	Seviteronel(100 mg/kg bid; oral administration for 25 days) reduced tumor volume in castrated male mice with xenografts[2].
Alias	VT-464

Chemical Properties

Molecular Weight	399.34
Formula	C18H17F4N3O3
Cas No.	1610537-15-9

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (100.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5041 mL	12.5207 mL	25.0413 mL	125.2066 mL
5 mM	0.5008 mL	2.5041 mL	5.0083 mL	25.0413 mL
10 mM	0.2504 mL	1.2521 mL	2.5041 mL	12.5207 mL
20 mM	0.1252 mL	0.6260 mL	1.2521 mL	6.2603 mL
50 mM	0.0501 mL	0.2504 mL	0.5008 mL	2.5041 mL
100 mM	0.0250 mL	0.1252 mL	0.2504 mL	1.2521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc