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Pregnenolone Carbonitrile

Catalog No. T21818 CAS 1434-54-4

Synonyms: Pregnenolone 16α-carbonitrile , 5-Pregnen-3β-ol-20-one-16α-carbonitrile

Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.

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Pregnenolone Carbonitrile Chemical Structure

Pregnenolone Carbonitrile, CAS 1434-54-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 169.00
50 mg	In stock	$ 249.00
100 mg	In stock	$ 373.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.
In vitro	Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults[4].
In vivo	In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels[2]. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA[3]. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression[4].

Synonyms	Pregnenolone 16α-carbonitrile , 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Molecular Weight	341.49
Formula	C22H31NO2
CAS No.	1434-54-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (87.85 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Carylyn J Marek, et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J. 2005 May 1;387(Pt 3):601-8. 2. Yang Xie, et al. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury. Hepatology. 2019 Sep;70(3):995-1010. 3. Simon Lowes, et al. The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat. Pharmaceutics. 2010 Mar 15;2(1):61-77. 4. Jeffrey Guzelian, et al. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci. 2006 Dec;94(2):379-87.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max Metabolism Compound Library Nuclear Receptor Compound Library Anti-Cancer Compound Library Anti-Metabolism Disease Compound Library Human Metabolite Library

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Keywords

Pregnenolone Carbonitrile 1434-54-4 Metabolism P450 CYPs Cytochrome P450 P4503A Pregnenolone 16α-carbonitrile orally 5-Pregnen-3b-ol-20-one-16a-carbonitrile 5-Pregnen-3beta-ol-20-one-16alpha-carbonitrile Inhibitor PXR cytochrome inhibit Pregnenolone 16α-carbonitrile Pregnenolone 16alpha-carbonitrile 5-Pregnen-3β-ol-20-one-16α-carbonitrile Pregnenolone 16a-carbonitrile inhibitor

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