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Pregnenolone Carbonitrile

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Purity:99.64%

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COA HNMR HPLC

Pregnenolone Carbonitrile

Catalog No. T21818Cas No. 1434-54-4

Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.

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Pack Size	Price	Availability	Quantity
5 mg	$49	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Product Introduction

Bioactivity

Description	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.
In vitro	Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults[4].
In vivo	In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels[2]. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA[3]. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression[4].
Alias	Pregnenolone 16α-carbonitrile , 5-Pregnen-3β-ol-20-one-16α-carbonitrile

Chemical Properties

Molecular Weight	341.49
Formula	C22H31NO2
Cas No.	1434-54-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (87.85 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9283 mL	14.6417 mL	29.2834 mL	146.4172 mL
5 mM	0.5857 mL	2.9283 mL	5.8567 mL	29.2834 mL
10 mM	0.2928 mL	1.4642 mL	2.9283 mL	14.6417 mL
20 mM	0.1464 mL	0.7321 mL	1.4642 mL	7.3209 mL
50 mM	0.0586 mL	0.2928 mL	0.5857 mL	2.9283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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