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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $698 | Backorder |
Description | Methysticin, a major kavalactone extracted from kava, can induce CYP1A1. |
In vivo | Methysticin (6 mg/kg) is administered orally once weekly for six months to 6-month-old transgenic APP/Psen1 mice. This treatment initiates activation of the Nrf2 pathway in the mice's hippocampus and cortex. Despite Methysticin not altering Aβ deposition in the brains of treated APP/Psen1 mice compared to controls, it significantly mitigates microgliosis, astrogliosis, and the secretion of pro-inflammatory cytokines TNF-α and IL-17A. Additionally, Methysticin markedly activates the Nrf2/ARE pathway specifically in the hippocampus and cortex, but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice, leading to a significant increase in the expression of both genes relative to untreated animals. |
Alias | DL-Methysticin, (±)-Methystici |
Molecular Weight | 274.27 |
Formula | C15H14O5 |
Cas No. | 20697-20-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 1 mg/mL (3.65 mM) DMSO: 5 mg/mL (18.23 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
DMSO
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