Methyl (E)-4-hydroxycinnamatee is found in several plants such as onion or Morinda citrifolia. It induces apoptosis in combination with Carnosic Acid and kills acute myeloid leukemia cells. It has antioxidant and antibacterial activity.
NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.
Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.
Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
Dehydroformouregine is a natural product of Piper, Piperaceae. The catalog number is TN3804 and the CAS number is 107633-69-2. Dehydroformouregine can be used as a reference standard.
3-(4-Methoxyphenyl)-1-(pyrrol-1-yl)propan-1-one is a natural product for research related to life sciences. The catalog number is TN2850 and the CAS number is 448905-82-6.
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa
1-(4-Methoxycinnamoyl)pyrrole is a natural product for research related to life sciences. The catalog number is TN2474 and the CAS number is 736140-70-8.
1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydromethysticin and Desmethoxy yangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.
3-Phenyl-1-(pyrrol-1-yl)propan-1-one is a natural product for research related to life sciences. The catalog number is TN2980 and the CAS number is 112448-69-8.
Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neurons and astroglia, decreases peak amplitude of voltage-gated Na+ channels in hippocampal neurons, and suppresses growth of Fusarium, Trichoderma, and Colletotrichum.
Isodihydrofutoquinol B is a natural product of Piper, Piperaceae. The catalog number is TN4282 and the CAS number is 62499-71-2. Isodihydrofutoquinol B can be used as a reference standard.
Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma.
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.
Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.Piperlonguminine is an inhibitor of Akt/mTOR signalling. It acts by promoting autophagy and mediating cancer cell death.
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.
Methyl trans-3-(3,4,5-trimethoxyphenyl)acrylate is a natural product for research related to life sciences. The catalog number is TN4556 and the CAS number is 20329-96-8.
Futokadsurin C can inhibit nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which is activated by lipopolysaccharide and interferon-gamma.
Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method.
Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-κB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM.
Methyl 3-(4-methoxyphenyl)propanoate is a natural product for research related to life sciences. The catalog number is TN4528 and the CAS number is 15823-04-8.
Ethyl 3-(4-methoxyphenyl)propanoate is a natural product for research related to life sciences. The catalog number is TN4019 and the CAS number is 22767-72-2.
4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid is a natural product of Piper, Piperaceae. The catalog number is TN3036 and the CAS number is 155051-85-7. 4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid can be used as a reference standard.
3,5-Diprenyl-4-hydroxybenzaldehyde is a natural product for research related to life sciences. The catalog number is TN2901 and the CAS number is 52275-04-4.
4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical and singlet oxygen scavenging properties.