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(-)-p-Bromotetramisole Oxalate

Catalog No. T6353 CAS 62284-79-1

Synonyms: (-)-对溴四咪唑草酸盐, L-p-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, (-)-p-Bromolevamisole oxalate

p-Bromotetramisole Oxalate is a potent and non-specific inhibitor of alkaline phosphatase.

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(-)-p-Bromotetramisole Oxalate, CAS 62284-79-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

p-Bromotetramisole Oxalate is a potent and non-specific inhibitor of alkaline phosphatase.

In vitro

Aurora A Inhibitor I is a 2,4-dianilinopyrimidine that selectively and potently inhibits Aurora A. Aurora A Inhibitor I effectively inhibits the proliferation of HCT116 and HT29 cells, with IC50 of 190 nM and 2.9 μM, respectively. The Aurora A selectivity of Aurora A Inhibitor I against Aurora B depends on a single amino acid (Thr217) of Aurora A. [1] In KCL-22 cells, Aurora A Inhibitor I (1-5 μM) increases G2/M cell fraction, induces histone H3 serine 10 phosphorylation, and suppresses mitotic Aurora A autophosphorylation on Thr288. Aurora A Inhibitor I (0.5-5 μM) also suppresses cell proliferation in KCL-22 cells, as well as BCR-ABL-negative leukemia cell lines KG-1 and HL-60. Aurora A Inhibitor I effectively induces apoptosis in KCL-22 cells at 5 μM. [2] In a recent study, Aurora A Inhibitor I is also found to inhibit cell growth of HCT116, HT29, and HeLa cells, with IC50 of 377.6 nM, 5.6 μM, and 416 nM. [3]

Synonyms	(-)-对溴四咪唑草酸盐, L-p-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, (-)-p-Bromolevamisole oxalate
Molecular Weight	373.22
Formula	C13H13BrN2O4S
CAS No.	62284-79-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 28 mg/mL (75 mM)

Ethanol: <1 mg/mL

DMSO: 69 mg/mL (184.9 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Onsgard-Meyer M,et al.Proc Soc Exp Biol Med. 1996 Nov;213(2):193-5.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Phosphatase Inhibitor Library Lipid Metabolism Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(-)-p-Bromotetramisole Oxalate 62284-79-1 代谢 Phosphatase Phosphorylase 6-Bromolevamisole oxalate ( ) p Bromotetramisole Oxalate L-p-Bromotetramisole oxalate inhibit Inhibitor ()pBromotetramisole Oxalate 6-Bromolevamisole (-)-p-Bromolevamisole oxalate inhibitor

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