T12080 |
MLS000544460
|
352336-36-8
|
98%
|
|
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM).MLS000544460 exhibits inhibitory effects on Eya2 phosphatas...
|
T25824 |
ML400
|
1908414-42-5
|
98%
|
|
ML400 is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
|
T61268 |
Vutiglabridin
|
1800188-47-9
|
98%
|
|
Vutiglabridin is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabri...
|
T67893 |
PTP1B-IN-22
|
86109-60-6
|
98%
|
|
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
|
T61699 |
Osunprotafib
|
2489404-97-7
|
98%
|
|
ABBV-CLS-484 is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for...
|
T11955 |
MB-07729
|
882755-95-5
|
98%
|
|
MB-07729 is a potent non-competitive inhibitor of fructose-1,6-bisphosphate with IC50 values of 189, 121 and 31 nM in rat, monkey and human, respectively, for th...
|
T35528 |
TD52
|
1798328-24-1
|
98%
|
|
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
|
T24073 |
PTP1B-IN-4
|
765317-72-4
|
98%
|
|
PTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
|
T3827 |
Rhein-8-glucoside calcium
|
113443-70-2
|
98%
|
|
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
|
TN2887 |
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
|
329975-47-5
|
98%
|
|
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
|
T3930 |
Taraxerol acetate
|
2189-80-2
|
98%
|
|
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
T11687 |
Itacitinib adipate
|
1334302-63-4
|
98%
|
|
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelo...
|
TN3335 |
Abyssinone V
|
77263-11-7
|
98%
|
|
Abyssinone V is a natural compound isolated from the stem bark of Erythrina melanacantha and an inhibitor of protein tyrosine phosphatase-1B (PTP1B).
|
T14037 |
3α-Aminocholestane
|
2206-20-4
|
98%
|
|
3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
|
T11735 |
K-Ras G12C-IN-1
|
1629265-17-3
|
98%
|
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
|
T12934 |
SMAP-2
|
1809068-70-9
|
98%
|
|
SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhib...
|
TN4551 |
Methyl orsellinate
|
3187-58-4
|
98%
|
|
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
|
T15243 |
Ertiprotafib
|
251303-04-5
|
98%
|
|
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
|
TN4064 |
Flavoglaucin
|
523-73-9
|
98%
|
|
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
|