T25824 |
ML400
|
1908414-42-5
|
98%
|
|
ML400 is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
|
T15243 |
Ertiprotafib
|
251303-04-5
|
98%
|
|
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
|
T10060L |
DT-061
|
1809427-19-7
|
98%
|
|
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
|
TN4064 |
Flavoglaucin
|
523-73-9
|
98%
|
|
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
|
T67893 |
PTP1B-IN-22
|
86109-60-6
|
98%
|
|
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
|
T3930 |
Taraxerol acetate
|
2189-80-2
|
98%
|
|
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
|
TN2913 |
3-Acetoxy-11-ursen-28,13-olide
|
35959-08-1
|
98%
|
|
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibit...
|
T16517 |
PGMI-004A
|
1313738-90-7
|
98%
|
|
PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1 μM).
|
T11735 |
K-Ras G12C-IN-1
|
1629265-17-3
|
98%
|
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
|
TN4551 |
Methyl orsellinate
|
3187-58-4
|
98%
|
|
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
|
T7381 |
TCS 401
|
243966-09-8
|
98%
|
|
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
|
TN2887 |
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
|
329975-47-5
|
98%
|
|
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
|
T3827 |
Rhein-8-glucoside calcium
|
113443-70-2
|
98%
|
|
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
|
T24263 |
KLH45
|
1632236-44-2
|
98%
|
|
KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
|
T16724 |
Razuprotafib
|
1008510-37-9
|
98%
|
|
Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inh...
|
T4671 |
BN82002
|
396073-89-5
|
98%
|
|
BN82002 is a synthetic inhibitor of CDC25 phophatases
|
TN3505 |
Beta-Peltoboykinolic acid
|
24778-48-1
|
98%
|
|
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cy...
|
T15166 |
DPM-1001
|
1471172-27-6
|
98%
|
|
DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
|
T10877 |
CPDA
|
1415834-63-7
|
98%
|
|
CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
|
T14037 |
3α-Aminocholestane
|
2206-20-4
|
98%
|
|
3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
|