Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	Product name	CAS No.	Purity
T25824	ML400	1908414-42-5	98%
T25824	ML400 is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
T15243	Ertiprotafib	251303-04-5	98%
T15243	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
T10060L	DT-061	1809427-19-7	98%
T10060L	DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
TN4064	Flavoglaucin	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
T67893	PTP1B-IN-22	86109-60-6	98%
T67893	PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
T3930	Taraxerol acetate	2189-80-2	98%
T3930	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
TN2913	3-Acetoxy-11-ursen-28,13-olide	35959-08-1	98%
TN2913	3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibit...
T16517	PGMI-004A	1313738-90-7	98%
T16517	PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1 μM).
T11735	K-Ras G12C-IN-1	1629265-17-3	98%
T11735	K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
TN4551	Methyl orsellinate	3187-58-4	98%
TN4551	Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
T7381	TCS 401	243966-09-8	98%
T7381	TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
TN2887	3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	329975-47-5	98%
TN2887	(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
T3827	Rhein-8-glucoside calcium	113443-70-2	98%
T3827	Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
T24263	KLH45	1632236-44-2	98%
T24263	KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
T16724	Razuprotafib	1008510-37-9	98%
T16724	Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inh...
T4671	BN82002	396073-89-5	98%
T4671	BN82002 is a synthetic inhibitor of CDC25 phophatases
TN3505	Beta-Peltoboykinolic acid	24778-48-1	98%
TN3505	Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cy...
T15166	DPM-1001	1471172-27-6	98%
T15166	DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
T10877	CPDA	1415834-63-7	98%
T10877	CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
T14037	3α-Aminocholestane	2206-20-4	98%
T14037	3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.