Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	Product name	CAS No.	Purity
T12080	MLS000544460	352336-36-8	98%
T12080	MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM).MLS000544460 exhibits inhibitory effects on Eya2 phosphatas...
T25824	ML400	1908414-42-5	98%
T25824	ML400 is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
T61268	Vutiglabridin	1800188-47-9	98%
T61268	Vutiglabridin is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabri...
T67893	PTP1B-IN-22	86109-60-6	98%
T67893	PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
T61699	Osunprotafib	2489404-97-7	98%
T61699	ABBV-CLS-484 is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for...
T11955	MB-07729	882755-95-5	98%
T11955	MB-07729 is a potent non-competitive inhibitor of fructose-1,6-bisphosphate with IC50 values of 189, 121 and 31 nM in rat, monkey and human, respectively, for th...
T35528	TD52	1798328-24-1	98%
T35528	TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
T24073	PTP1B-IN-4	765317-72-4	98%
T24073	PTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
T3827	Rhein-8-glucoside calcium	113443-70-2	98%
T3827	Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
TN2887	3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	329975-47-5	98%
TN2887	(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
T3930	Taraxerol acetate	2189-80-2	98%
T3930	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
TN3525	Boehmenan	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T11687	Itacitinib adipate	1334302-63-4	98%
T11687	Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelo...
TN3335	Abyssinone V	77263-11-7	98%
TN3335	Abyssinone V is a natural compound isolated from the stem bark of Erythrina melanacantha and an inhibitor of protein tyrosine phosphatase-1B (PTP1B).
T14037	3α-Aminocholestane	2206-20-4	98%
T14037	3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
T11735	K-Ras G12C-IN-1	1629265-17-3	98%
T11735	K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
T12934	SMAP-2	1809068-70-9	98%
T12934	SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhib...
TN4551	Methyl orsellinate	3187-58-4	98%
TN4551	Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
T15243	Ertiprotafib	251303-04-5	98%
T15243	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
TN4064	Flavoglaucin	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...