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Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research
Cat. No. Product name CAS No. Purity Chemical Structure
T25824 ML400 1908414-42-5 98%
ML400 is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
T15243 Ertiprotafib 251303-04-5 98%
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
T10060L DT-061 1809427-19-7 98%
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
TN4064 Flavoglaucin 523-73-9 98%
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
T67893 PTP1B-IN-22 86109-60-6 98%
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
T3930 Taraxerol acetate 2189-80-2 98%
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
TN2913 3-Acetoxy-11-ursen-28,13-olide 35959-08-1 98%
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibit...
T16517 PGMI-004A 1313738-90-7 98%
PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1 μM).
T11735 K-Ras G12C-IN-1 1629265-17-3 98%
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
TN4551 Methyl orsellinate 3187-58-4 98%
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
T7381 TCS 401 243966-09-8 98%
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
TN2887 3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid 329975-47-5 98%
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
T3827 Rhein-8-glucoside calcium 113443-70-2 98%
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
T24263 KLH45 1632236-44-2 98%
KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
T16724 Razuprotafib 1008510-37-9 98%
Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inh...
T4671 BN82002 396073-89-5 98%
BN82002 is a synthetic inhibitor of CDC25 phophatases
TN3505 Beta-Peltoboykinolic acid 24778-48-1 98%
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cy...
T15166 DPM-1001 1471172-27-6 98%
DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
T10877 CPDA 1415834-63-7 98%
CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
T14037 3α-Aminocholestane 2206-20-4 98%
3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
ML400
T25824
ML400 is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
Ertiprotafib
T15243
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
DT-061
T10060L
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
Flavoglaucin
TN4064
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
PTP1B-IN-22
T67893
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
Taraxerol acetate
T3930
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
3-Acetoxy-11-ursen-28,13-olide
TN2913
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibit...
PGMI-004A
T16517
PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1 μM).
K-Ras G12C-IN-1
T11735
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
Methyl orsellinate
TN4551
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
TCS 401
T7381
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
TN2887
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
Rhein-8-glucoside calcium
T3827
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
KLH45
T24263
KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
Razuprotafib
T16724
Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inh...
BN82002
T4671
BN82002 is a synthetic inhibitor of CDC25 phophatases
Beta-Peltoboykinolic acid
TN3505
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cy...
DPM-1001
T15166
DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
CPDA
T10877
CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
3α-Aminocholestane
T14037
3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
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