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Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research
Cat No. product name
T39658 RMC-4630 RMC-4630 是 SHP2 的抑制剂。
T5878 β-Glycerophosphate disodium salt pentahydrate β-Glycerol phosphate disodium salt pentahydrate is a protein phosphatase inhibitor.
T7150 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T22215 1-Naphthyl phosphate potassium salt 1-Naphthyl phosphate potassium salt inhibits non-specific phosphatase.
T3564 SHP099 SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). S...
T7078 NSC 95397 NSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively).
T0945 Cyclosporin A Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhib...
T23132 Pentamidine dihydrochloride Pentamidine Dihydrochloride is an antimicrobial agent.
T4915 β-Glycerophosphate disodium salt hydrate β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase...
T23133 Pentamidine Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor gro...
T14841 BVT948 BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
T9205 NCGC00378430 NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
T10877 CPDA CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
T6911 NSC-87877 disodium NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation i...
T9156 CDC25B-IN-2 BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.
T6S2116 Ginkgolic acid C17:1 1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, an...
T1654 Pentamidine isethionate Pentamidine isethionate is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
T4852 Trimyristin Within the cell, glyceryl trimyristate is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ...
T0825 Ebselen Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is th...
T2P2923 Stearic acid 1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. ...
T12901 SHIP2-IN-1 SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 µM),and used in the research of Alzheimer’s disease.
TN2111 Prunin Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-re...
T7323 BCI-215 BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling
T22136 PRL-3 Inhibitor I BR-1 is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.
T7411 Rbin-1 Rbin-1 is a potent,specific inhibitor of eukaryotic ribosome biogenesis.
TN1859 Licoflavone A Licoflavone A is a natural product
T16724 Razuprotafib Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inh...
T11139 (E/Z)-BCI (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pa...
T3827 Rhein-8-glucoside calcium Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
T6353 (-)-p-Bromotetramisole Oxalate p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
T12519 Sodium metatungstate Sodium metatungstate is a potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase)(Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1,...
T0308 Etidronic acid Etidronic is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
T2160 Suramin Sodium Salt Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
TP2054L Calcineurin Autoinhibitory Peptide acetate Calcineurin Autoinhibitory Peptide acetate is a selectivecalcineurin phosphatase inhibitor(IC50 ~ 10 μM). Calcineurin Autoinhibitory Peptide acetate can be used ...
T11929 M2N12 M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selectiv...
T9744 MP07-66 MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.
T8573 NSC 65809 NSC 65809 is a selective inhibitor of R15B.
T19389 L-Ascorbic acid 2-phosphate magnesium L-Ascorbic acid 2-phosphate magnesium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.It is a long-acting vitamin C derivati...
T4449 LB100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
T22276 Bis(maltolato)oxovanadium(IV) BMOV is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic pro...
T3962 TPI-1 TPI-1 is a SHP-1 inhibitor.
T3045 Salubrinal Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T2417 Sal003 Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
T5204 Microcystin-LR Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.
T0494 Tetramisole hydrochloride Tetramisole is used as an anthelmintic.
T2481 Ascomycin Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
T1210 Sodium etidronate Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, eti...
T16350 NSC-87877 NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual...
T16762 RMC-4550 RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
T5708 LUPENONE Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhib...
RMC-4630
T39658
RMC-4630 是 SHP2 的抑制剂。
β-Glycerophosphate disodium salt pentahydrate
T5878
β-Glycerol phosphate disodium salt pentahydrate is a protein phosphatase inhibitor.
BTdCPU
T7150
BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
1-Naphthyl phosphate potassium salt
T22215
1-Naphthyl phosphate potassium salt inhibits non-specific phosphatase.
SHP099
T3564
SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM)....
NSC 95397
T7078
NSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively).
Cyclosporin A
T0945
Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhib...
Pentamidine dihydrochloride
T23132
Pentamidine Dihydrochloride is an antimicrobial agent.
β-Glycerophosphate disodium salt hydrate
T4915
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatas...
Pentamidine
T23133
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor gro...
BVT948
T14841
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
NCGC00378430
T9205
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
CPDA
T10877
CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
NSC-87877 disodium
T6911
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation i...
CDC25B-IN-2
T9156
BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.
Ginkgolic acid C17:1
T6S2116
1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, an...
Pentamidine isethionate
T1654
Pentamidine isethionate is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
Trimyristin
T4852
Within the cell, glyceryl trimyristate is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ...
Ebselen
T0825
Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is th...
Stearic acid
T2P2923
1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. ...
SHIP2-IN-1
T12901
SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 µM),and used in the research of Alzheimer’s disease.
Prunin
TN2111
Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-re...
BCI-215
T7323
BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling
PRL-3 Inhibitor I
T22136
BR-1 is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.
Rbin-1
T7411
Rbin-1 is a potent,specific inhibitor of eukaryotic ribosome biogenesis.
Licoflavone A
TN1859
Licoflavone A is a natural product
Razuprotafib
T16724
Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) i...
(E/Z)-BCI
T11139
(E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB p...
Rhein-8-glucoside calcium
T3827
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
(-)-p-Bromotetramisole Oxalate
T6353
p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
Sodium metatungstate
T12519
Sodium metatungstate is a potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase)(Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase...
Etidronic acid
T0308
Etidronic is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Suramin Sodium Salt
T2160
Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
Calcineurin Autoinhibitory Peptide acetate
TP2054L
Calcineurin Autoinhibitory Peptide acetate is a selectivecalcineurin phosphatase inhibitor(IC50 ~ 10 μM). Calcineurin Autoinhibitory Peptide acetate can be used...
M2N12
T11929
M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly s...
MP07-66
T9744
MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.
NSC 65809
T8573
NSC 65809 is a selective inhibitor of R15B.
L-Ascorbic acid 2-phosphate magnesium
T19389
L-Ascorbic acid 2-phosphate magnesium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.It is a long-acting vitamin C derivati...
LB100
T4449
LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
Bis(maltolato)oxovanadium(IV)
T22276
BMOV is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic pro...
TPI-1
T3962
TPI-1 is a SHP-1 inhibitor.
Salubrinal
T3045
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
Sal003
T2417
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
Microcystin-LR
T5204
Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.
Tetramisole hydrochloride
T0494
Tetramisole is used as an anthelmintic.
Ascomycin
T2481
Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
Sodium etidronate
T1210
Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, eti...
NSC-87877
T16350
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits du...
RMC-4550
T16762
RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
LUPENONE
T5708
Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhib...
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