Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

KLH45

🥰Excellent
Catalog No. T24263Cas No. 1632236-44-2
Alias KLH-45, KLH 45

KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).

KLH45

KLH45

🥰Excellent
Purity: 100%
Catalog No. T24263Alias KLH-45, KLH 45Cas No. 1632236-44-2
KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
Pack SizePriceAvailabilityQuantity
5 mg$35In Stock
10 mg$56In Stock
25 mg$112In Stock
50 mg$179In Stock
100 mg$292In Stock
1 mL x 10 mM (in DMSO)$35In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "KLH45"

Select Batch
Purity:100%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
In vitro
In Neuro2A cells, KLH45 (25 nM) completely inhibits DDHD2 (>95%)[1]. In fatty acid-supplemented DDHD2-expressing cells, KLH45 (2 μM) increases LD formation and selectively blocks DDHD2 activity[2].
In vivo
KLH45 (20 mg/kg) significantly elevates brain triglycerides in DDHD2−/− mice[1].
AliasKLH-45, KLH 45
Chemical Properties
Molecular Weight458.48
FormulaC24H25F3N4O2
Cas No.1632236-44-2
SmilesFC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CCCCC1
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 162.0 mg/mL (353.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1811 mL10.9056 mL21.8112 mL109.0560 mL
5 mM0.4362 mL2.1811 mL4.3622 mL21.8112 mL
10 mM0.2181 mL1.0906 mL2.1811 mL10.9056 mL
20 mM0.1091 mL0.5453 mL1.0906 mL5.4528 mL
50 mM0.0436 mL0.2181 mL0.4362 mL2.1811 mL
100 mM0.0218 mL0.1091 mL0.2181 mL1.0906 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy KLH45 | purchase KLH45 | KLH45 cost | order KLH45 | KLH45 chemical structure | KLH45 in vivo | KLH45 in vitro | KLH45 formula | KLH45 molecular weight