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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $58 | In Stock | |
10 mg | $93 | In Stock | |
25 mg | $187 | In Stock | |
50 mg | $298 | In Stock | |
100 mg | $433 | In Stock | |
1 mL x 10 mM (in DMSO) | $58 | In Stock |
Description | KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM). |
In vitro | In Neuro2A cells, KLH45 (25 nM) completely inhibits DDHD2 (>95%)[1]. In fatty acid-supplemented DDHD2-expressing cells, KLH45 (2 μM) increases LD formation and selectively blocks DDHD2 activity[2]. |
In vivo | KLH45 (20 mg/kg) significantly elevates brain triglycerides in DDHD2−/− mice[1]. |
Alias | KLH-45, KLH 45 |
Molecular Weight | 458.48 |
Formula | C24H25F3N4O2 |
Cas No. | 1632236-44-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 162.0 mg/mL (353.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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