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Disodium monofluorophosphate
🥰Excellent
Catalog No. T0745Cas No. 10163-15-2
Alias NSC248
Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
Disodium monofluorophosphate
🥰Excellent
Catalog No. T0745Alias NSC248Cas No. 10163-15-2
Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 g | $29 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase. |
| Targets&IC50 | Phosphorylase phosphatase:0.5 mM(Ki), Pyruvate kinase:3.4 mM(Ki), ALP:69 μM(Ki) |
| In vitro | Monofluorophosphate showed potent activity against bone immobilization in vivo. Drinking water containing 50 ppm Monofluorophosphate showed a significant increase in bone disease in mobile and immobile tibia (1.48 and 0.98 mM, respectively, and 0.79 and 0.40 mM, respectively) as compared to the fluoride-free water group. Monofluorophosphate increased the rate of bone mineralization and counteracted immobilization-induced decreases in bone thickness, ash content, and specific gravity without altering the Ca/P ratio of ash.Monofluorophosphate had no effect on the specific gravity of immobilized and immobilized tibiae in rats. |
| In vivo | Monofluorophosphate showed potent activity against bone immobilization in vivo. Drinking water containing 50 ppm Monofluorophosphate showed a significant increase in bone disease in mobile and immobile tibia (1.48 and 0.98 mM, respectively, and 0.79 and 0.40 mM, respectively) as compared to the fluoride-free water group. Monofluorophosphate increased the rate of bone mineralization and counteracted immobilization-induced decreases in bone thickness, ash content, and specific gravity without altering the Ca/P ratio of ash.Monofluorophosphate had no effect on the specific gravity of immobilized and immobilized tibiae in rats. |
| Alias | NSC248 |
| Molecular Weight | 143.95 |
| Formula | FNa2O3P |
| Cas No. | 10163-15-2 |
| Smiles | O=P([O-])(F)[O-].[Na+].[Na+] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble）  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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