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Suramin
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Catalog No. T75303Cas No. 145-63-1
Suramin is a dual-function inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and protein tyrosine phosphatases (PTPases), with antiparasitic, anticancer, and anti-angiogenesis properties, inhibiting sirtuins and DNA topoisomerase II.
Suramin
😃Good
Catalog No. T75303Cas No. 145-63-1
Suramin is a dual-function inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and protein tyrosine phosphatases (PTPases), with antiparasitic, anticancer, and anti-angiogenesis properties, inhibiting sirtuins and DNA topoisomerase II.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Suramin is a dual-function inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and protein tyrosine phosphatases (PTPases), with antiparasitic, anticancer, and anti-angiogenesis properties, inhibiting sirtuins and DNA topoisomerase II. |
| Targets&IC50 | Topo II:5 μM, SIRT1:297 nM, SIRT5:22 μM, SIRT2:1.15 μM |
| In vitro | Low concentrations of 35 μM (50 μg/mL) and 70 μM (100 μg/mL) Suramin were not cytotoxic to prefascial adipocytes. However, high concentrations of 105 μM (150 μg/mL) and 140 μM (200 μg/mL) showed cytotoxic effects by reducing cell viability. Suramin (0-140 μM) stimulated and promoted lipogenic differentiation of FSCs in a time - and dose-dependent manner. [1] Suramin activates Nrf2 and correspondingly inhibits the activated B cell (NF-κB) nuclear factor kappa light chain enhancer and mitogen-activated protein kinase (MAPK) pathway, thereby reducing IL-1β-stimulated chondrocyte inflammation and ECM degeneration. Suramin repolarizes M1 macrophages to M2 phenotype, further reducing apoptosis of chondrocytes. [2] |
| In vivo | Rats were intraperitoneally injected with 50 mg/kg Suramin once a week for 4 weeks, and the results showed that Suramin could slightly promote rat adipogenesis in vivo. [1] |
| Molecular Weight | 1297.28 |
| Formula | C51H40N6O23S6 |
| Cas No. | 145-63-1 |
| Smiles | O=C(NC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2C)C(=O)NC3=CC=C(C4=CC(=CC(=C34)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC5=CC=CC(=C5)C(=O)NC6=CC(=CC=C6C)C(=O)NC7=CC=C(C8=CC(=CC(=C78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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