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Osunprotafib

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Purity:98.01%

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COA HNMR HPLC

Osunprotafib

Catalog No. T61699Cas No. 2489404-97-7

ABBV-CLS-484 (Osunprotafib) is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for the treatment of neoplasms, esophageal cancer, and digestive disorders.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
1 mg	$455	In Stock
5 mg	$1,360	In Stock
10 mg	$2,150	In Stock
25 mg	$3,730	In Stock
50 mg	$5,595	In Stock

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Product Introduction

Bioactivity

Description	ABBV-CLS-484 (Osunprotafib) is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for the treatment of neoplasms, esophageal cancer, and digestive disorders.
In vitro	ABBV-CLS-484 acts simultaneously on tumor cells and the host immune system, inducing unique transcriptional changes in myeloid and lymphocyte populations in the tumor microenvironment, enhancing the activation and effector functions of CD8+ T cells, while reducing T cell exhaustion and dysfunction. Expression of classical genes.[2]
In vivo	ABBV-CLS-484 promotes anti-tumor immunity as a single agent, and when combined with anti-PD-1, results in significant tumor regression, even in models that are resistant to anti-PD-1 treatment, such as 4T1 and EMT6.[3]
Alias	AC 484, Osunprotafib, AC484, ABBV-CLS-484

Chemical Properties

Molecular Weight	385.45
Formula	C17H24FN3O4S
Cas No.	2489404-97-7

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 56.2 mg/mL (145.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5944 mL	12.9719 mL	25.9437 mL	129.7185 mL
5 mM	0.5189 mL	2.5944 mL	5.1887 mL	25.9437 mL
10 mM	0.2594 mL	1.2972 mL	2.5944 mL	12.9719 mL
20 mM	0.1297 mL	0.6486 mL	1.2972 mL	6.4859 mL
50 mM	0.0519 mL	0.2594 mL	0.5189 mL	2.5944 mL
100 mM	0.0259 mL	0.1297 mL	0.2594 mL	1.2972 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc