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BCI hydrochloride
🥰Excellent
Catalog No. T10486LCas No. 95130-23-7
Alias (E)-BCI hydrochloride
BCI hydrochloride ((E)-BCI hydrochloride) is a selective dual-specificity phosphatase 6 (DUSP6) inhibitor that inhibits RANKL-mediated osteoclastogenesis and attenuates oophorectomy-induced bone loss.BCI hydrochloride has anti-inflammatory activity, reduces reactive oxygen species (ROS) production, and partially reverses AE-induced bone loss. BCI hydrochloride has anti-inflammatory activity and can reduce reactive oxygen species (ROS) production, partially reverse AE-induced cytotoxicity, and increase ERK activity, which can be used to study inflammatory diseases.
BCI hydrochloride
🥰Excellent
Purity: 99.95%
Catalog No. T10486LAlias (E)-BCI hydrochlorideCas No. 95130-23-7
BCI hydrochloride ((E)-BCI hydrochloride) is a selective dual-specificity phosphatase 6 (DUSP6) inhibitor that inhibits RANKL-mediated osteoclastogenesis and attenuates oophorectomy-induced bone loss.BCI hydrochloride has anti-inflammatory activity, reduces reactive oxygen species (ROS) production, and partially reverses AE-induced bone loss. BCI hydrochloride has anti-inflammatory activity and can reduce reactive oxygen species (ROS) production, partially reverse AE-induced cytotoxicity, and increase ERK activity, which can be used to study inflammatory diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $86 | In Stock |
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Purity:99.95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BCI hydrochloride ((E)-BCI hydrochloride) is a selective dual-specificity phosphatase 6 (DUSP6) inhibitor that inhibits RANKL-mediated osteoclastogenesis and attenuates oophorectomy-induced bone loss.BCI hydrochloride has anti-inflammatory activity, reduces reactive oxygen species (ROS) production, and partially reverses AE-induced bone loss. BCI hydrochloride has anti-inflammatory activity and can reduce reactive oxygen species (ROS) production, partially reverse AE-induced cytotoxicity, and increase ERK activity, which can be used to study inflammatory diseases. |
| In vitro | BCI hydrochloride (100 ng/mL; 24 hr) was able to down-regulate DUSP6 expression in RAW264.7 macrophages.BCI hydrochloride (0-1 nM; 24 hr) inhibited DUSP6 expression, as well as IL-1β and IL-6 production in lipopolysaccharide (LPS)-activated macrophages.BCI hydrochloride (0-4 nM; 24 hr), in turn reduced reactive oxygen species (ROS) production and activated the Nrf2 pathway in LPS-activated macrophages. [1][2] |
| Alias | (E)-BCI hydrochloride |
| Molecular Weight | 353.89 |
| Formula | C22H24ClNO |
| Cas No. | 95130-23-7 |
| Smiles | Cl.O=C1C=2C=CC=CC2C(NC3CCCCC3)C1=CC=4C=CC=CC4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (28.26 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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