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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $121 | In Stock | |
5 mg | $248 | In Stock | |
10 mg | $495 | In Stock | |
25 mg | $791 | In Stock | |
50 mg | $1,120 | In Stock | |
100 mg | $1,490 | In Stock | |
500 mg | $2,970 | In Stock | |
1 mL x 10 mM (in DMSO) | $289 | In Stock |
Description | (E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. |
In vitro | (E/Z)-BCI hydrochloride (2-10 μM; 72 hours) significantly decreases cell viability in a time and dose-dependent manner in gastric epithelial cell GES1, GC cell lines, and AGS cell lines. (E/Z)-BCI hydrochloride (0.5-4 μM; 24 hours) significantly inhibits DUSP6 expression in LPS-activated macrophages. (E/Z)-BCI hydrochloride inhibits cell proliferation, migration, and invasion in a receptor-independent manner and enhances Cisplatin (CDDP) cytotoxicity (enhances CDDP-induced cell death and apoptosis) at pharmacological concentrations in gastric cancer (GC) cells. (E/Z)-BCI hydrochloride (0.5-2 μM; 24 hours) treatment significantly inhibits the expression of IL-1β, TNF-α, and IL-6 mRNA in LPS-activated macrophages. (E/Z)-BCI hydrochloride decreases ROS production and activates the Nrf2 pathway in LPS-activated macrophages. |
In vivo | (E/Z)-BCI hydrochloride treatment enhances cisplatin efficacy in PDX models. |
Alias | NSC 150117 |
Molecular Weight | 317.42 |
Formula | C22H23NO |
Cas No. | 15982-84-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 20 mg/mL (60.00 mM), Sonication is recommended. DMSO: 50 mg/mL (157.52 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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