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Rosiptor
Catalog No. TQ0032Cas No. 782487-28-9
Alias AQX-1125
Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
Rosiptor
Catalog No. TQ0032Alias AQX-1125Cas No. 782487-28-9
Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $113 | In Stock | |
| 5 mg | $289 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $648 | In Stock | |
| 50 mg | $912 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $318 | In Stock |
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Purity:99.53%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects. |
| In vitro | In MOLT-4 but not Jurkat cells, Rosiptor (0.1-10 μM, 30 minutes) inhibits Akt activation [1]. |
| In vivo | Rosiptor (10 mg/kg, p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability [1]. Rosiptor (3-30 mg/kg, p.o., daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity [2]. |
| Cell Research | Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation) [1]. Concentration: 0.1, 1, 10 μM. Incubation Time: 30 minutes |
| Animal Research | Animal Model: 6-8 weeks old male CD-1 mice[1]. Dosage: 3, 10, 30 mg/kg. Administration: p.o., daily for 3 days |
| Alias | AQX-1125 |
| Molecular Weight | 321.5 |
| Formula | C20H35NO2 |
| Cas No. | 782487-28-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 145 mg/mL (451 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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