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Ro 90-7501

🥰Excellent
Catalog No. T16773Cas No. 293762-45-5
Alias RO-90-7501

Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest. Ro 90-7501 also exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.

Ro 90-7501

Ro 90-7501

🥰Excellent
Purity: 99.80%
Catalog No. T16773Alias RO-90-7501Cas No. 293762-45-5
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest. Ro 90-7501 also exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$68In Stock
10 mg$123In Stock
25 mg$272In Stock
50 mg$463In Stock
100 mg$787In Stock
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Purity:99.80%
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Product Introduction

Bioactivity
Description
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest. Ro 90-7501 also exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.
In vitro
Compared to control HeLa and ME-180 cells, Ro 90-7501 significantly enhances radiation sensitivity. Following irradiation, Ro 90-7501 markedly increases apoptosis and impairs the cell cycle. Post-irradiation, Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2[2].
RO 90-7501 itself does not affect IFN-β and NFκB promoter activity but significantly enhances poly I:C-induced IFN-β promoter activation and dose-dependently inhibits NF-κB activation. Treatment with RO 90-7501 significantly enhances the antiviral activity of poly I:C[1].
In vivo
Treatment with Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; continuous for 21 days; female BALB/c nude mice) significantly delays tumor growth and markedly reduces tumor volume[2].
AliasRO-90-7501
Chemical Properties
Molecular Weight340.38
FormulaC20H16N6
Cas No.293762-45-5
SmilesNC1=CC=C(C=C1)C1=NC2=C(N1)C=C(C=C2)C1=NC2=C(N1)C=C(N)C=C2
Relative Density.1.443g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (88.14 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9379 mL14.6895 mL29.3789 mL146.8946 mL
5 mM0.5876 mL2.9379 mL5.8758 mL29.3789 mL
10 mM0.2938 mL1.4689 mL2.9379 mL14.6895 mL
20 mM0.1469 mL0.7345 mL1.4689 mL7.3447 mL
50 mM0.0588 mL0.2938 mL0.5876 mL2.9379 mL

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