Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1/PD-L1 expression, and strengthens anti-tumor immunity. It also stimulates T cell activation, impedes M2 macrophage polarization, and suppresses tumor progression in MC38 isogenic mouse models. |
In vitro | LYP-IN-4 (compound D14) also inhibits other protein tyrosine phosphatases (PTP), with IC50 values of 13.7 μM for PTP1B and 12.3 μM for PTPN1B [1]. |
In vivo | LYP-IN-4 (compound D14), administered at 25 mg/kg via oral gavage twice daily for 14 consecutive days, significantly inhibited tumor growth and reduced tumor volume in the MC38 genetic model, without affecting mouse body weight [1]. |
Molecular Weight | 593 |
Formula | C29H21ClN2O8S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.