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Calyculin A
😃Good
Catalog No. T14859Cas No. 101932-71-2
Alias (-)-Calyculin A
Calyculin A ((-)-Calyculin A), a toxicant in the Japanese marine sponge CDiscodermia calyxC, is a selective and potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), inducing hyperactivation of cryopreserved bovine spermatozoa and inhibiting radiation-induced gammaH2AX DNA repair disease in human lymphocytes. gammaH2AX DNA repair foci in human lymphocytes.
Calyculin A
😃Good
Purity: 98%
Catalog No. T14859Alias (-)-Calyculin ACas No. 101932-71-2
Calyculin A ((-)-Calyculin A), a toxicant in the Japanese marine sponge CDiscodermia calyxC, is a selective and potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), inducing hyperactivation of cryopreserved bovine spermatozoa and inhibiting radiation-induced gammaH2AX DNA repair disease in human lymphocytes. gammaH2AX DNA repair foci in human lymphocytes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 μg | $498 | 35 days |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Calyculin A ((-)-Calyculin A), a toxicant in the Japanese marine sponge CDiscodermia calyxC, is a selective and potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), inducing hyperactivation of cryopreserved bovine spermatozoa and inhibiting radiation-induced gammaH2AX DNA repair disease in human lymphocytes. gammaH2AX DNA repair foci in human lymphocytes. |
| Targets&IC50 | PP1:2 nM, PP2A:0.5-1 nM |
| In vitro | METHODS: CalycuLin A was used to treat human osteosarcoma MG63 cells at different concentrations (0, 1, 2, 5, 10 nM) for 24 hours. The induction of apoptosis by CalycuLin A was determined using WST-8 assay, nuclear fragmentation, and DNA ladder formation. RESULTS: Calyculin A induced apoptosis in human osteosarcoma MG63 cells, characterized by the phosphorylation of p65NF-κB [2]. |
| Alias | (-)-Calyculin A |
| Molecular Weight | 1009.17 |
| Formula | C50H81N4O15P |
| Cas No. | 101932-71-2 |
| Smiles | C[C@@]1(C)[C@@]2(O[C@]([C@H](C[C@@H]([C@@H]([C@@H]([C@@H](/C=C(/C(=C/C=C/C(=C\C#N)/C)/C)\C)C)O)C)O)OC)([C@@H]1OP(=O)(O)O)[H])O[C@@H](C/C=C/C=3N=C([C@H](CCNC([C@H]([C@H]([C@H](COC)N(C)C)O)O)=O)C)OC3)[C@@H](C)[C@H](O)C2 |
| Relative Density. | 1.25g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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