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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $32 | In Stock | |
10 mg | $52 | In Stock | |
25 mg | $101 | In Stock | |
50 mg | $137 | In Stock | |
100 mg | $243 | In Stock | |
500 mg | $593 | In Stock | |
1 mL x 10 mM (in DMSO) | $57 | In Stock |
Description | (-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase. |
In vitro | Aurora A Inhibitor I is a 2,4-dianilinopyrimidine that selectively and potently inhibits Aurora A. Aurora A Inhibitor I effectively inhibits the proliferation of HCT116 and HT29 cells, with IC50 of 190 nM and 2.9 μM, respectively. The Aurora A selectivity of Aurora A Inhibitor I against Aurora B depends on a single amino acid (Thr217) of Aurora A. [1] In KCL-22 cells, Aurora A Inhibitor I (1-5 μM) increases G2/M cell fraction, induces histone H3 serine 10 phosphorylation, and suppresses mitotic Aurora A autophosphorylation on Thr288. Aurora A Inhibitor I (0.5-5 μM) also suppresses cell proliferation in KCL-22 cells, as well as BCR-ABL-negative leukemia cell lines KG-1 and HL-60. Aurora A Inhibitor I effectively induces apoptosis in KCL-22 cells at 5 μM. [2] In a recent study, Aurora A Inhibitor I is also found to inhibit cell growth of HCT116, HT29, and HeLa cells, with IC50 of 377.6 nM, 5.6 μM, and 416 nM. [3] |
Alias | L-p-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, (-)-p-Bromolevamisole oxalate |
Molecular Weight | 373.22 |
Formula | C13H13BrN2O4S |
Cas No. | 62284-79-1 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 28 mg/mL (75 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (160.76 mM) ![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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