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Okadaic acid
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Catalog No. T16381Cas No. 78111-17-8
Okadaic acid is a potent polyether marine toxin that accumulates in the digestive glands of marine mollusks.Okadaic acid is a highly potent and selective protein phosphatase (PP) inhibitor, inhibiting PP1, PP2A, PP3, PP4, and PP5.Okadaic acid activates Wnt/β-catenin signaling in human HepaRG cells. catenin signaling in human HepaRG cells.
Okadaic acid
😃Good
Catalog No. T16381Cas No. 78111-17-8
Okadaic acid is a potent polyether marine toxin that accumulates in the digestive glands of marine mollusks.Okadaic acid is a highly potent and selective protein phosphatase (PP) inhibitor, inhibiting PP1, PP2A, PP3, PP4, and PP5.Okadaic acid activates Wnt/β-catenin signaling in human HepaRG cells. catenin signaling in human HepaRG cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg (124.2 μM * 250 μL in Ethanol)" | $143 | 35 days | |
| 50 μg (124.2 μM * 500 μL in Ethanol) | $250 | 35 days | |
| 100 μg (124.2 μM * 1 mL in Ethanol) | $415 | 35 days |
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β-Glycerophosphate disodium salt hydrate
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Concentration:0.1 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Okadaic acid is a potent polyether marine toxin that accumulates in the digestive glands of marine mollusks.Okadaic acid is a highly potent and selective protein phosphatase (PP) inhibitor, inhibiting PP1, PP2A, PP3, PP4, and PP5.Okadaic acid activates Wnt/β-catenin signaling in human HepaRG cells. catenin signaling in human HepaRG cells. |
| Targets&IC50 | PP2:0.5 nM, PP4:0.1 nM, PP1:10-15 nM, PP1:15-50 nM, PP3:4 nM, PP3:3.7-4 nM, PP5:3.5 nM, PP2A:0.1-0.3 nM |
| In vitro | Okadaic acid, at concentrations ranging from 0 to 100 nM and after treatment periods of 24 or 48 hours, is capable of inhibiting the proliferation of AGS, MNK-45, and Caco 2 cells[3]. |
| In vivo | Okadaic Acid (100 μg; icv; single dose) can be used in male Wistar rats (250-300 g) to establish an Alzheimer's disease model[6]. |
| Molecular Weight | 805 |
| Formula | C44H68O13 |
| Cas No. | 78111-17-8 |
| Smiles | O[C@H]1[C@@]2(O[C@]([C@@H](/C=C/[C@@H]3O[C@]4(CC3)O[C@@]5([C@@](CC4)(O[C@]([C@H](C[C@H](C)[C@]6(O[C@]7(CC[C@H]6C)CCCCO7)[H])O)(C(=C)[C@H]5O)[H])[H])[H])C)(CC(C)=C2)[H])O[C@H](C[C@@](C(O)=O)(C)O)CC1 |
| Relative Density. | 1.0795 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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