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IACS-13909
🥰Excellent
Catalog No. T9196Cas No. 2160546-07-4
Alias BBP-398
IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
IACS-13909
🥰Excellent
Purity: 98.80%
Catalog No. T9196Alias BBP-398Cas No. 2160546-07-4
IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 91 € | In Stock | |
| 5 mg | 227 € | In Stock | |
| 10 mg | 359 € | In Stock | |
| 25 mg | 511 € | In Stock | |
| 50 mg | 723 € | In Stock | |
| 100 mg | 937 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 249 € | In Stock |
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Purity:98.80%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway. |
| Targets&IC50 | SHP2:15.7 nM |
| In vitro | IACS-13909 potently impeded proliferation of tumors harboring a broad spectrum of activated RTKs as the oncogenic driver. |
| In vivo | In EGFR-mutant osimertinib-resistant NSCLC models with EGFR-dependent and EGFR-independent resistance mechanisms, IACS-13909, administered as a single agent or in combination with osimertinib, potently suppressed tumor cell proliferation?in vitro?and caused tumor regression?in vivo. |
| Alias | BBP-398 |
| Molecular Weight | 377.27 |
| Formula | C17H18Cl2N6 |
| Cas No. | 2160546-07-4 |
| Smiles | CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |
| Relative Density. | 1.402 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (23.86 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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