Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $58 | In Stock | |
2 mg | $85 | In Stock | |
5 mg | $143 | In Stock | |
10 mg | $223 | In Stock | |
25 mg | $369 | In Stock | |
50 mg | $520 | In Stock | |
100 mg | $696 | In Stock | |
500 mg | $1,390 | In Stock | |
1 mL x 10 mM (in DMSO) | $157 | In Stock |
Description | DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with IC50 of 1.43 μM. DJ001 promotes the regeneration of hematopoietic stem cells. |
In vitro | Compared with control culture, DJ001 (5-1000 ng/mL; 3-7 days; BM KSL cells) treatment can increase the percentage and number of BM KSL cells in culture. DJ001 treatment also significantly increased the number of colony forming cells (CFC) in BM KSL cells cultured for 3 days. The BM KSL cells were irradiated with 300 cGy and placed in a medium containing 1 μg/mL DJ001 and without 1 μg/mL DJ001 (containing 20 μng/mL thrombopoietin, 100 μng/mL stem cell factor (SCF), 50 μng/mL Flt3 Body, TSF). 3 days. Compared with control culture, DJ001 treatment can improve the recovery rate of BM CFC and multipotent colony forming unit-granulocyte-like erythrocyte mononuclear megakaryocyte (CFU-GEMM) colonies[1]. |
In vivo | DJ001 inhibits radiation-induced HSC apoptosis by activating RhoGTPase, RAC1 and inducing BCL-XL. DJ001 (5 μg/kg; subcutaneous injection; duration 24 hours; female C57BL/6 mice) significantly reduced the percentage of apoptotic BM KSL cells in C57BL/6 mice 24h after 500°cGy TBI[1]. |
Molecular Weight | 268.27 |
Formula | C15H12N2O3 |
Cas No. | 2161305-12-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225 mg/mL (838.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.