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Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $41 | In Stock | |
10 mg | $65 | In Stock | |
25 mg | $118 | In Stock | |
50 mg | $178 | In Stock | |
100 mg | $268 | In Stock | |
200 mg | $393 | In Stock | |
1 mL x 10 mM (in DMSO) | $44 | In Stock |
Description | Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor. |
Targets&IC50 | R15B-PP1c holophosphatase:33 nM(Kd) |
In vitro | Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment. |
In vivo | Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease. |
Molecular Weight | 291.13 |
Formula | C10H12Cl2N4O2 |
Cas No. | 2242616-04-0 |
Smiles | CC(O)=O.NC(=N)N\N=C\c1cccc(Cl)c1Cl |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (137.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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