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NSC 65809

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Purity:99.84%

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COA HNMR LCMS

NSC 65809

Catalog No. T8573Cas No. 94023-67-3

NSC-65809 (Raphin1) is a selective inhibitor of R15B.

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Pack Size	Price	Availability
1 mg	$133	In Stock
2 mg	$198	In Stock
5 mg	$298	In Stock
10 mg	$453	In Stock
25 mg	$747	In Stock
50 mg	$1,050	In Stock
100 mg	$1,420	In Stock
1 mL x 10 mM (in DMSO)	$267	In Stock

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Product Introduction

Bioactivity

Description	NSC-65809 (Raphin1) is a selective inhibitor of R15B.
In vitro	In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment
In vivo	Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
Alias	3-[(2,3-dichlorophenyl)methylene]carbazamidine, Raphin1

Chemical Properties

Molecular Weight	231.08
Formula	C8H8Cl2N4
Cas No.	94023-67-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35 mg/mL (151.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3275 mL	21.6375 mL	43.2751 mL	216.3753 mL
5 mM	0.8655 mL	4.3275 mL	8.6550 mL	43.2751 mL
10 mM	0.4328 mL	2.1638 mL	4.3275 mL	21.6375 mL
20 mM	0.2164 mL	1.0819 mL	2.1638 mL	10.8188 mL
50 mM	0.0866 mL	0.4328 mL	0.8655 mL	4.3275 mL
100 mM	0.0433 mL	0.2164 mL	0.4328 mL	2.1638 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc