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CDC25B-IN-2

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Purity:99.12%

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COA HNMR HPLC

CDC25B-IN-2

Catalog No. T9156Cas No. 134271-74-2

BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.

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Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$59	In Stock
10 mg	$97	In Stock
25 mg	$197	In Stock
50 mg	$318	In Stock
100 mg	$478	In Stock
500 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock

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Product Introduction

Bioactivity

Description

BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.

In vitro

The proliferation and cell viability of all cell lines were inhibited by treatment with 5?μM BIA.The IC50 values at 3 days were 1.7?±?0.1?μM for HT1080, 2.6?±?0.4?μM for MCF cells, 2.6?±?0.5?μM for MDA-MB-231 cells, and 2.4?±?0.4?μM for SKBR3 cells. Moreover, HT1080 cells stably overexpressing TMBIM6 showed high sensitivity to BIA[1].BIA decreases the binding between TMBIM6 and mTORC2, we performed a gel filtration assay in TMBIM6-overexpressing HT1080 cells after treatment with BIA during 24?h[1].

Chemical Properties

Molecular Weight	268.27
Formula	C15H12N2O3
Cas No.	134271-74-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (242.29 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7276 mL	18.6379 mL	37.2759 mL	186.3794 mL
5 mM	0.7455 mL	3.7276 mL	7.4552 mL	37.2759 mL
10 mM	0.3728 mL	1.8638 mL	3.7276 mL	18.6379 mL
20 mM	0.1864 mL	0.9319 mL	1.8638 mL	9.3190 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7276 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8638 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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