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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $49 | In Stock |
Description | 3α-Aminocholestane (5α-Cholestan-3α-amine) is a potent inhibitor of inositol-5'-phosphatase 1 (SHIP1) containing the SH2 structural domain (IC50 : 2.5 μM) for research and immune-related diseases. |
In vitro | MM cells were treated with increasing concentrations of 3α-Aminocholestane (3AC) for 48 hours. After cell lysis, proteins were separated by SDS-PAGE and probed with antibodies against SHIP1, SHIP2, and PTEN. The results indicate that treatment with3α-Aminocholestane (3AC)leads to proteasomal degradation of the SHIP1 protein[1]. |
In vivo | NOD/SCID/γcIL2R (NSG) mutant mice were inoculated with 1 × 10^7 MM cells (OPM2) via intraperitoneal injection. Six hours later, the mice received the first injection of 3α-Aminocholestane (3AC), followed by daily injections for the next 7 days, and subsequently, injections every two weeks for the following 15 weeks. The results indicate that treatment with 3α-Aminocholestane (3AC) inhibits the growth of MM cells in vivo.[1]. |
Alias | 5α-Cholestan-3α-amine |
Molecular Weight | 387.68 |
Formula | C27H49N |
Cas No. | 2206-20-4 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | Ethanol: 30 mg/mL (77.38 mM) DMSO: <0.1 mg/mL | ||||||||||
Solution Preparation Table | |||||||||||
Ethanol
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