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Razuprotafib
🥰Excellent
Catalog No. T16724Cas No. 1008510-37-9
Alias AKB-9778
Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.
Razuprotafib
🥰Excellent
Purity: 95.93%
Catalog No. T16724Alias AKB-9778Cas No. 1008510-37-9
Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $253 | In Stock | |
| 5 mg | $413 | In Stock | |
| 10 mg | $619 | In Stock | |
| 25 mg | $1,050 | In Stock | |
| 50 mg | $1,370 | In Stock | |
| 100 mg | $1,790 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $533 | In Stock |
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Purity:95.93%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury. |
| Targets&IC50 | HPTPß:50 nM |
| In vitro | Razuprotafib inhibits the phosphatase activity of VE-PTP with an IC50 of 17 pM.
Razuprotafib inhibits the phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib inhibits HPTPη (IC50 = 36 pM) . Razuprotafib inhibits HPTPγ (IC50 = 100 pM). Razuprotafib 0.17 to 50 μM HUVEC 10 minutes in WB concentration-dependent phosphorylation of TIE2 and downstream components of the TIE2 signaling pathway, including eNOS, AKT, and ERK. |
| In vivo | Rho-VEGF–transgenic mice s.c. injection 20 mg/kg 12 hours promotes phosphorylation of TIE2 in retinal endothelial cells
Rho-VEGF mice s.c. injection 10-20 mg/kg twice daily for 7 days suppresses subretinal neovascularization. |
| Alias | AKB-9778 |
| Molecular Weight | 586.7 |
| Formula | C26H26N4O6S3 |
| Cas No. | 1008510-37-9 |
| Smiles | COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1cccs1 |
| Relative Density. | 1.450 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (170.44 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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