Shopping Cart

Remove All

Your shopping cart is currently empty

PTP1B-IN-4

Resource Download

PTP1B-IN-4

Catalog No. T24073Cas No. 765317-72-4

PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
500 μg	$153	35 days
1 mg	$280	35 days
5 mg	$660	35 days
10 mg	$1,170	35 days

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
Targets&IC50	PTP1B:8 μM (IC50)
In vitro	In CHO cells overexpressing human IR, PTP1B-IN-4 (250 µM) stimulates the phosphorylation of insulin receptors. PTP1B-IN-4 induces phosphorylation of IRS-1 and Akt which are proteins downstream of the insulin receptor[3].
Alias	NUN 17724, PTP1B-inhibitor-2, PTP1B IN 2, PTP1B-IN-2, PTP1B-inhibitor-4, FRJ, PTP1B inhibitor 4, NUN17724, PTP1B inhibitor 2, PTP1BIN2, NUN-17724

Chemical Properties

Molecular Weight	741.45
Formula	C26H19Br2N3O7S3
Cas No.	765317-72-4

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90 mg/mL (121.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3487 mL	6.7435 mL	13.4871 mL	67.4354 mL
5 mM	0.2697 mL	1.3487 mL	2.6974 mL	13.4871 mL
10 mM	0.1349 mL	0.6744 mL	1.3487 mL	6.7435 mL
20 mM	0.0674 mL	0.3372 mL	0.6744 mL	3.3718 mL
50 mM	0.0270 mL	0.1349 mL	0.2697 mL	1.3487 mL
100 mM	0.0135 mL	0.0674 mL	0.1349 mL	0.6744 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PTP1B-IN-4

PTP1B-IN-4

PTP1B-IN-4

Inhibitors Related to "PTP1B-IN-4"

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Tech Support

Keywords