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F1063-0967

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COA HNMR LCMS

F1063-0967

Catalog No. T4308Cas No. 613225-56-2

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$46	In Stock
10 mg	$74	In Stock
50 mg	$197	In Stock
100 mg	$288	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock

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Product Introduction

Bioactivity

Description	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
Targets&IC50	DUSP26:11.62 μM
In vitro	At concentration above 0.1 μM, F1063-0967 remarkably induces IMR32 cell apoptosis. F1063-0967 induces apoptosis in IMR-32 cell line with an IC50 value of 4.13 μM. F1063-0967 has no effect on HL7702 cell line, and little inhibition effect on SH-SY5Y cell line.
Cell Research	The IMR-32 cells are plated in 96-well plates with 1×103 cells per well. After the cells are allowed to settle for 24 h, F1063-0967 (0, 10, 1, and 0.1 μM) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 μM) is added, then MTT assays are carried out after 72 h.

Chemical Properties

Molecular Weight	484.59
Formula	C24H24N2O5S2
Cas No.	613225-56-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (123.82 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0636 mL	10.3180 mL	20.6360 mL	103.1800 mL
5 mM	0.4127 mL	2.0636 mL	4.1272 mL	20.6360 mL
10 mM	0.2064 mL	1.0318 mL	2.0636 mL	10.3180 mL
20 mM	0.1032 mL	0.5159 mL	1.0318 mL	5.1590 mL
50 mM	0.0413 mL	0.2064 mL	0.4127 mL	2.0636 mL
100 mM	0.0206 mL	0.1032 mL	0.2064 mL	1.0318 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc