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EWP 815

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Catalog No. T61214Cas No. 20231-01-0

EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2].

EWP 815

EWP 815

🥰Excellent
Catalog No. T61214Cas No. 20231-01-0
EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2].
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5 mg64 €In Stock
10 mg107 €In Stock
25 mg215 €In Stock
50 mg349 €In Stock
100 mg561 €In Stock
500 mg1.197 €In Stock
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Product Introduction

Bioactivity
Description
EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2].
In vitro
EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [3H]Ins(1,4,5)P3 5-phosphatase in particulate and soluble fractions with IC50s of 6 μM and 8 μM, respectively.[1]
EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4)P2 phosphatase rather than Ins(1,4,5)P3 5-phosphatase with the mean [3H]Ins(1,4)P2/mean [3H]InsP recovery ratio of 2.6.[1]
EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5)P3 binding.[1]
In vivo
EWP 815 (50 mg/kg; i.p.; administered 30 minutes before euthanasia) inhibits dopamine β-hydroxylase activity in mice, reducing the amount of 3 H-α-Me-NA by 12%.[2]
Chemical Properties
Molecular Weight350.59
FormulaC12H22N4S4
Cas No.20231-01-0
SmilesC(SSC(=S)N1CCN(C)CC1)(=S)N2CCN(C)CC2
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 1 mg/ml, Sonication is recommended.

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