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BN82002
🥰Excellent
Catalog No. T4671Cas No. 396073-89-5
Alias CDC25 Phosphatase Inhibitor I
BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases
BN82002
🥰Excellent
Purity: 99.91%
Catalog No. T4671Alias CDC25 Phosphatase Inhibitor ICas No. 396073-89-5
BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $38 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $122 | In Stock | |
| 25 mg | $222 | In Stock | |
| 50 mg | $372 | In Stock | |
| 100 mg | $556 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:99.91%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases |
| Targets&IC50 | CDC25B2:3.9 μM, CDC25C:5.4 μM, CDC25B3:6.3 μM, CDC25A:2.4 μM, CDC25C-cat:4.6 μM |
| In vitro | The in vitro impact of BN82002 on the proliferation of various human tumor cell lines has been assessed, with menadione serving as a control due to its documented proliferation inhibitory properties. All tested cell lines exhibit sensitivity to both BN82002 and menadione, demonstrating concentration-dependent inhibition within the low micromolar range. Among these, the pancreatic cancer cell line MIA PaCa-2 is the most affected by BN82002, showing an IC50 of 7.2 μM, while the colon cancer cell line HT-29 shows the least sensitivity with an IC50 of 32.6 μM. This range of inhibitory concentration for BN82002 closely matches that observed with menadione (5-15 μM). Further findings indicate that a 50 μM concentration of BN82002 completely halts cell proliferation. Although the influence on cell cycle distribution is relatively mild, there is a noted decrease in the S phase and an increase in cells with G1 and G2 DNA content, hinting at cell cycle arrest at various stages due to BN82002 treatment. |
| Alias | CDC25 Phosphatase Inhibitor I |
| Molecular Weight | 359.42 |
| Formula | C19H25N3O4 |
| Cas No. | 396073-89-5 |
| Smiles | COc1cc(cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1O)N(C)C |
| Relative Density. | 1.216 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (417.34 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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