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BN82002 hydrochloride

BN82002 hydrochloride
BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family, inhibiting CDC25A, CDC25B2, CDC25B3, CDC25C, and [25C-cat] with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively, and exhibits approximately 20-fold greater selectivity over [CD45 tyrosine phosphatase].
Catalog No. T38447Cas No. 1049740-43-3
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BN82002 hydrochloride

Catalog No. T38447Cas No. 1049740-43-3
BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family, inhibiting CDC25A, CDC25B2, CDC25B3, CDC25C, and [25C-cat] with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively, and exhibits approximately 20-fold greater selectivity over [CD45 tyrosine phosphatase].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$525 days
5 mg$977-10 days
1 mL x 10 mM (in DMSO)$987-10 days
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Product Introduction

Bioactivity
Description
BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family, inhibiting CDC25A, CDC25B2, CDC25B3, CDC25C, and [25C-cat] with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively, and exhibits approximately 20-fold greater selectivity over [CD45 tyrosine phosphatase].
Targets&IC50
CDC25B2:3.9 μM (IC50), CDC25A:2.4 μM (IC50), CDC25B3:6.3 μM (IC50), CDC25C:5.4 μM (IC50), CDC25C-cat:4.6 μM (IC50)
In vitro
The in vitro impact of BN82002 on the proliferation of various human tumor cell lines was assessed, employing Menadione, a known proliferation inhibitor, as a benchmark. BN82002 and Menadione were observed to inhibit proliferation across all tested cell lines in a concentration-dependent fashion within the low micromolar range. Particularly, the pancreatic cancer cell line MIA PaCa-2 demonstrated the highest sensitivity to BN82002 with an IC 50 of 7.2 μM, while the colon cancer cell line HT-29 exhibited the least sensitivity with an IC 50 of 32.6 μM. This sensitivity pattern closely mirrors that seen with Menadione (5-15 μM). Additionally, it was found that a 50 μM concentration of BN82002 effectively halted cell proliferation. However, this arrest saw only a slight shift in the cell cycle, characterized by a minor decrease in the S phase and a rise in cells at both G1 and G2 DNA content stages, indicating BN82002-induced arrest occurs at various cell cycle phases[1].
Chemical Properties
Molecular Weight395.88
FormulaC19H26ClN3O4
Cas No.1049740-43-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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