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SHP389
🥰Excellent
Catalog No. T39726Cas No. 2235394-90-6
Alias SHP 389
SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.
SHP389
🥰Excellent
Catalog No. T39726Alias SHP 389Cas No. 2235394-90-6
SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $165 | In Stock | |
| 5 mg | $413 | In Stock | |
| 10 mg | $689 | In Stock | |
| 25 mg | $1,490 | In Stock | |
| 50 mg | $2,480 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $455 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research. |
| Targets&IC50 | SHP2:36 nM |
| In vitro | SHP389 is an allosteric inhibitor of SHP2 with IC50 of 36 nM for SHP2. SHP389 showed high clearance in rat liver microsomes in vitro (Cl = 26.1 μL/min/mg, T1/2 = 53.2 min), large distribution volume (3.9 L/kg), terminal half-life of 2.7 h, and oral bioavailability of 2%. [2] |
| In vivo | SHP389 modulates MAPK signaling in vivo[1]. |
| Alias | SHP 389 |
| Molecular Weight | 484.98 |
| Formula | C23H29ClN8O2 |
| Cas No. | 2235394-90-6 |
| Smiles | N[C@H]1C2(CCN(CC2)C3=NC=4C(C(=O)N3C)=C(NN4)C=5C(Cl)=C(NC6CC6)N=CC5)CO[C@H]1C |
| Relative Density. | 1.67 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (164.96 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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