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LMPTP Inhibitor 1 Dihydrochloride is a compound selectively targeting low molecular weight protein tyrosine phosphatase (LMPTP), exhibiting potent inhibitory activity with an IC50 value of 0.8 μM for LMPTP-A.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $70 | In Stock | |
5 mg | $172 | In Stock | |
10 mg | $278 | In Stock | |
25 mg | $517 | In Stock | |
50 mg | $748 | In Stock | |
100 mg | $1,050 | In Stock | |
1 mL x 10 mM (in DMSO) | $223 | In Stock |
Description | LMPTP Inhibitor 1 Dihydrochloride is a compound selectively targeting low molecular weight protein tyrosine phosphatase (LMPTP), exhibiting potent inhibitory activity with an IC50 value of 0.8 μM for LMPTP-A. |
Targets&IC50 | LMPTPA:0.8 μM |
In vitro | LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50?of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes[1]. |
In vivo | LMPTP inhibitor 1 dihydrochloride, an orally bioavailable compound, achieves an approximate mean serum concentration of 680 nM following 0.03% w/w administration and exceeds 3 μM with 0.05% w/w dosage. Notably, it reverses diabetes in obese mice. At a concentration of 0.05% w/w, it effectively inhibits LMPTP activity, leading to a significant enhancement in glucose tolerance and a reduction in fasting insulin levels in diabetic DIO mice, with no impact on body weight[1]. |
Molecular Weight | 517.53 |
Formula | C28H38Cl2N4O |
Cas No. | 2310135-46-5 |
Smiles | Cl.Cl.CCN(CC)C(=O)c1ccc(cc1)-c1cc(NCCCN2CCCCC2)c2ccccc2n1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 50 mg/mL (96.61 mM), Sonication is recommended. DMSO: 64 mg/mL (123.66 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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